Secoxyloganin is a secoiridoid glycoside that has been found in L. japonica and has diverse biological activities. It is active against E. coli and S. aureus in a disc assay when used at a concentration of 2 mg/disc. Secoxyloganin is cytotoxic to human dermal fibroblasts (IC50 = 78.1 μM). In vivo, secoxyloganin (10 mg/ml) prevents hen egg white lysozyme-induced decreases in tail vein blood flow, a marker of allergic inflammation, in hen egg white lysozyme-sensitized mice.
