VX 702

$25 - $5328

Product nameVX 702
Cas No745833-23-2
MFC19H12F4N4O2
MW404.32
MDL NumberMFCD11616590

Synonyms

6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX 702;6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide VX-702;VX 702 6-[(Aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-3-pyridinecarboxamide;VX702;VX-702;2-(2,4-Difluorophenyl)-6-(1-(2,6-difluorophenyl)ureido)nicotinamide;CS-1840;3-Pyridinecarboxamide, 6-[(aminocarbonyl)(2,6-difluorophenyl)amino]-2-(2,4-difluorophenyl)-

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Price

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TCI Chemical Sigma-Aldrich Cayman Chemical Arctom Crysdot TRC Usbiological Biorbyt Ltd ApexBio Technology Matrix Scientific Adipogen Life Sciences Medical Isotopes, Inc. Apolloscientific ChemScene Biosynth Carbosynth DC Chemicals
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2mg 2.5mg 5mg 10mg 20mg 10mm(in1mldmso) 25mg 50mg 100mg 200mg 250mg 1g 5g

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Brand	Packaging	Price	Product name
Adipogen Life Sciences SYN-1093-M100	100mg	$378	VX-702
ApexBio Technology A8687	100mg	$209	VX-702
ApexBio Technology A8687	200mg	$319	VX-702
ApexBio Technology A8687	25mg	$77	VX-702
ApexBio Technology A8687	10mM(in1mLDMSO)	$83	VX-702
ApexBio Technology A8687	50mg	$141	VX-702
Apolloscientific BISN0171	10mg	$86	VX-702
Apolloscientific BISN0171	50mg	$247	VX-702
Apolloscientific BISN0171	100mg	$443	VX-702
Arctom CFN60370	20mg	$168	VX-702

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Properties

Boiling point	555.2±60.0 °C(Predicted)
Density	1.503
storage temp.	-20°C
solubility	Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 2 mg/ml)
form	solid
pka	10.65±0.50(Predicted)
color	White
Stability	Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChI	1S/C19H12F4N4O2/c20-9-4-5-10(14(23)8-9)16-11(18(24)28)6-7-15(26-16)27(19(25)29)17-12(21)2-1-3-13(17)22/h1-8H,(H2,24,28)(H2,25,29)
InChIKey	FYSRKRZDBHOFAY-UHFFFAOYSA-N
SMILES	Fc1c(c(ccc1)F)N(c2nc(c(cc2)C(=O)N)c3c(cc(cc3)F)F)C(=O)N
CAS DataBase Reference	745833-23-2

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

VX-702 is a third generation inhibitor of p38 mitogen-activated protein (MAP) kinases, binding to both p38α and p38β (Kd = 3.7 and 17 nM, respectively) in an ATP-competitive fashion. It inhibits IL-6, IL-1β, and TNF-α production in LPS-primed blood with IC50 values of 59, 122, and 99 ng/ml, respectively. VX-702, at 1 μM, inhibits activation of p38 in platelets by thrombin, U-46619 , or collagen but does not block platelet aggregation in response to collagen. Although orally active, VX-702 provides only transient suppression of biomarkers of inflammation in ongoing rheumatoid arthritis.

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Suppliers and manufacturers

career henan chemical co

$7.00/1KG

VX 702

CAS: 745833-23-2
TargetMol Chemicals Inc.

$45.00/10mg

VX-702

CAS:745833-23-2
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.
SUZHOU SENFEIDA CHEMICAL CO.,LTD
Zhengzhou Anbu Chem Co.,Ltd

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