Teneligliptin

$44 - $1815

Product nameTeneligliptin
Cas No760937-92-6
MFC22H30N6OS
MW426.58
MDL NumberMFCD13195565

Synonyms

teneligliptin;3-[[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]carbonyl]thiazolidine;Methanone,[(2S,4S)-4-[4-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)-1-piperazinyl]-2-pyrrolidinyl]-3-thiazolidinyl-;Teneligptin WS;[(2S,4S)-4-[4-(5-methyl-2-phenylpyrazol-3-yl)piperazin-1-yl]pyrrolidin-2-yl]-(1,3-thiazolidin-3-yl)methanone;API (Teneligliptin free base);Teliglietin;Teneligliptin (MP-513)

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Price

37 prices

Brand less more

Arctom Crysdot ACHEMBLOCK aablocks TRC ChemScene American Custom Chemicals Corporation DC Chemicals
Package less more

5mg 10mg 25mg 50mg 100mg 10mm*1mlindmso(solid+solvent) 1g 250mg 10mm*1mlindmso(solution)

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Brand	Packaging	Price	Product name
aablocks AA00G3N9	10mg	$52	Teneligliptin
aablocks AA00G3N9	5mg	$44	Teneligliptin
aablocks AA00G3N9	50mg	$99	Teneligliptin
aablocks AA00G3N9	25mg	$75	Teneligliptin
aablocks AA00G3N9	250mg	$469	Teneligliptin
ACHEMBLOCK AD264958	100MG	$315	Teneligliptin
ACHEMBLOCK AD264958	250MG	$605	Teneligliptin
ACHEMBLOCK AD264958	1G	$1815	Teneligliptin
American Custom Chemicals Corporation API0014166	100MG	$959.7	TENELIGLIPTIN
American Custom Chemicals Corporation API0014166	5MG	$502.54	TENELIGLIPTIN

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Properties

Melting point	>100°C (dec.)
Boiling point	663.4±55.0 °C(Predicted)
Density	1.38
storage temp.	Refrigerator
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	8.70±0.10(Predicted)
color	Off-White
InChIKey	WGRQANOPCQRCME-PMACEKPBSA-N
SMILES	C([C@@H]1C[C@H](N2CCN(C3N(C4=CC=CC=C4)N=C(C)C=3)CC2)CN1)(N1CCSC1)=O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

Teneligliptin was approved in September 2012 in Japan for the treatment of patients with Type 2 diabetes mellitus (T2DM). Teneligliptin is a member of the dipeptidyl peptidase 4 (DPP-4) inhibitor class of antidiabetes agents. DPP-4 is an enzyme that degrades GLP-1, a 30-amino acid peptide that is secreted in response to food intake. GLP-1 stimulates insulin secretion and inhibits glucagon secretion, which leads to lower levels of plasma glucose. Teneligliptin is one of a growing numbers of DPP-4 inhibitors to be approved worldwide. The discovery of teneligliptin was guided by structure-based design, with a key element being binding of the phenyl group in the S2 pocket, which not only increases potency for DPP-4, but also improves selectivity versus DPP-8 and DPP- 9. Teneligliptin is a potent inhibitor of DPP-4 in the enzyme inhibition assay (IC₅₀=0.37 nM).

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Suppliers and manufacturers

career henan chemical co

$1000.00

Teneligliptin

CAS:760937-92-6
ChemExpress
Capot Chemical Co.,Ltd.
Shanghai Daken Advanced Materials Co.,Ltd
Anqing Chico Pharmaceutical Co., Ltd.
CONIER CHEM AND PHARMA LIMITED
ANHUI WITOP BIOTECH CO., LTD
Xi'an MC Biotech, Co., Ltd.
AFINE CHEMICALS LIMITED
Finetech Industry Limited

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