P270：Do not eat, drink or smoke when using this product.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501：Dispose of contents/container to..…
Description
Tomatidine is a steroidal alkaloid found in skins and leaves of tomatoes. It has been shown to suppress NF-κB signaling in LPS-stimulated macrophages, blocking induced expression of iNOS and COX-2. It is a reported functional inhibitor of acid sphingomyelinase. Tomatidine also has antibacterial properties, blocking the replication of S. aureus variants that are pathogenic in cystic fibrosis more potently than normal strains (MICs = 0.12 and >16 μg/ml, respectively). It prevents skeletal muscle atrophy associated with fasting or spinal cord injury in mice. Tomatidine has also been used as a negative control for cyclopamine in studies involving signaling mediated by the hedgehog pathway.
