SU 11274

$44 - $2501.5

Product nameSU 11274
Cas No658084-23-2
MFC28H30ClN5O4S
MW568.09
MDL NumberMFCD08276928

Synonyms

PKI-SU11274;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide;N-(3-Chlorophenyl)-N-methyl-3-[[3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl]methylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide SU11274;SU 11274, >=98%;Met Kinase Inhibitor;(Z)-N-(3-Chlorophenyl)-3-((3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl)methy;(3z)-n-(3-chlorophenyl)-3-({3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1h-pyrrol-2-yl}methylene)-n-methyl-2-oxo-2,3-dihydro-1h-indole-5-sulfonamide;SU 11274，SU 11274

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Price

27 prices

Brand less more

Sigma-Aldrich Cayman Chemical Arctom TRC Biorbyt Ltd ApexBio Technology ChemScene American Custom Chemicals Corporation Biosynth Carbosynth DC Chemicals
Package less more

500μg 5mg 1mg 10mm(in1mldmso) 10mg 25mg 50mg 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
American Custom Chemicals Corporation API0004248	5MG	$348.6	SU 11274
American Custom Chemicals Corporation API0004248	100MG	$2501.5	SU 11274
ApexBio Technology A2678	100mg	$715	SU 11274
ApexBio Technology A2678	100mg	$787	SU11274
ApexBio Technology A2678	25mg	$330	SU11274
ApexBio Technology A2678	5mg	$77	SU11274
ApexBio Technology A2678	10mM(in1mLDMSO)	$88	SU11274
Arctom CFN60187	10mg	$268	SU 11274
Biorbyt Ltd orb154635	100mg	$615.4	SU11274 (PKI-SU11274)
Biorbyt Ltd orb154635	1g	$2395.3	SU11274 (PKI-SU11274)

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Properties

Density	1.401±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 10 mg/mL at 60 °C
pka	11.62±0.20(Predicted)
form	powder
color	orange
InChIKey	FPYJSJDOHRDAMT-KQWNVCNZSA-N
SMILES	CN1CCN(CC1)C(=O)c2c(C)[nH]c(\C=C3/C(=O)Nc4ccc(cc34)S(=O)(=O)N(C)c5cccc(Cl)c5)c2C

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in a many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed BaF3 cells and cancer cell lines.

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Suppliers and manufacturers

career henan chemical co

$1.00/1KG

(3Z)-N-(3-chlorophenyl)-3-[[3,5-dimethyl-4-(4-methylpiperazine-1-carbonyl)-1H-pyrrol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamide

CAS:658084-23-2
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Biochempartner
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Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
Nantong HI-FUTURE Biology Co., Ltd.

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