SL0101

$57 - $1800

Product nameSL0101
Cas No77307-50-7
MFC25H24O12
MW516.45
MDL NumberMFCD09842349

Synonyms

3-[(3,4-Di-O-acetyl-6-deoxy-α-L-Mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;Kaempferol 3-O-(3'',4''-di-O-acetyl-alpha-L-rhamnopyranoside);SL0101;2-(4-Hydroxyphenyl)-3-(3-O,4-O-diacetyl-α-L-rhamnopyranosyloxy)-5,7-dihydroxy-4H-1-benzopyran-4-one;2-(4-Hydroxyphenyl)-4-oxo-5,7-dihydroxy-4H-1-benzopyran-3-yl 3-O,4-O-diacetyl-α-L-rhamnopyranoside;3-(3-O,4-O-Diacetyl-α-L-rhamnopyranosyloxy)-4',5,7-trihydroxyflavone;3-[(3-O,4-O-Diacetyl-6-deoxy-α-L-mannopyranosyl)oxy]4',5,7-trihydroxyflavone;SL 0101-1

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Price

18 prices

Brand less more

Sigma-Aldrich Cayman Chemical CSNpharm Tocris TRC Usbiological ApexBio Technology Medical Isotopes, Inc. ChemScene DC Chemicals
Package less more

1 500μg 1mg 5mg 10mg 100mg 250mg 1g

Clear All Done

Brand	Packaging	Price	Product name
ApexBio Technology B9008	1mg	$299	SL0101-1
ApexBio Technology B9008	5mg	$929	SL0101-1
Cayman Chemical 11704	5mg	$395	SL 0101-1
Cayman Chemical 11704	10mg	$547	SL 0101-1
Cayman Chemical 11704	500μg	$57	SL 0101-1
Cayman Chemical 11704	1mg	$100	SL 0101-1
ChemScene CS-0003824	1mg	$150	SL0101-1
ChemScene CS-0003824	5mg	$360	SL0101-1
CSNpharm CSN20281	1mg	$138	SL0101
DC Chemicals DC8239	100mg	$500	SL0101-1

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Properties

Melting point	128-132°C
Boiling point	753.0±60.0 °C(Predicted)
Density	1.57±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	Acetone (Slightly), Methanol (Slightly)
form	Yellow solid
pka	6.20±0.40(Predicted)
color	Pale Yellow to Brown

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H302：Harmful if swallowed

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The p90 ribosomal S6 kinases (RSK) 1-4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. SL 0101-1 is a kaempferol glycoside, isolated from the tropical plant F. refracta, that selectively inhibits RSK2 with an IC50 value of 89 nM (Ki = 1 μM) without interfering with upstream activators of RSK, including ERK, MEK, EGFR, and PKC. At 100 μM, SL 0101-1 inhibits the proliferation of MCF-7 breast cancer cells, arresting cells in the G1 phase of the cell cycle. SL 0101-1 has been used to characterize the intracellular signaling events associated with angiotensin II-induced tyrosine kinase activation with a concentration of 30 μM attenuating angiotensin II-induced cell proliferation.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

$250.00/1mg

SL 0101-1

CAS:77307-50-7
BOC Sciences
InvivoChem
ShenZhen Trendseen Biological Technology Co.,Ltd.
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Shanghai Boyle Chemical Co., Ltd.
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.

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