SC-560

$19 - $2561

Product nameSC-560
Cas No188817-13-2
MFC17H12ClF3N2O
MW352.74
MDL NumberMFCD02179214

Synonyms

SC-560;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE;SC-560 Assay Reagent;1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-Methoxyphenyl)-3-(trifluoroMethyl)-;5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole;5-(4-Chlorophenyl);SC-560 - CAS 188817-13-2 - Calbiochem

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Price

40 prices

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TCI Chemical Sigma-Aldrich Cayman Chemical Chemenu Crysdot Tocris TRC Usbiological Biorbyt Ltd ApexBio Technology AK Scientific Chem-Impex ChemScene American Custom Chemicals Corporation Biosynth Carbosynth Ambeed DC Chemicals
Package less more

5mg 10mg 1mg 10mm(in1mldmso) 25mg 50mg 100mg 250mg 1000mg 1g 10

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Brand	Packaging	Price	Product name
AK Scientific 1879BB	1g	$2561	5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Ambeed A252197	5mg	$23	SC-560
Ambeed A252197	10mg	$38	SC-560
Ambeed A252197	25mg	$63	SC-560
Ambeed A252197	1g	$560	SC-560
American Custom Chemicals Corporation INB0000997	1MG	$561.51	SC-560
American Custom Chemicals Corporation INB0000997	5MG	$646.69	SC-560
American Custom Chemicals Corporation INB0000997	25MG	$822.24	SC-560
ApexBio Technology B6786	25mg	$240	SC-560
ApexBio Technology B6786	5mg	$60	SC-560

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Properties

Melting point	63 °C
Boiling point	440.6±45.0 °C(Predicted)
Density	1.33
storage temp.	2-8°C
solubility	DMSO: >20mg/mL
form	Off-white solid
pka	-3?+-.0.10(Predicted)
color	White to Light yellow to Light orange

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

H335：May cause respiratory irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352：IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321：Specific treatment (see … on this label).

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P362：Take off contaminated clothing and wash before reuse.

Description

SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 μM. Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.

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Suppliers and manufacturers

career henan chemical co

$1.00/1KG

SC-560

CAS:188817-13-2
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Hefei TNJ Chemical Industry Co.,Ltd.
TargetMol Chemicals Inc.
Aladdin Scientific
Amadis Chemical Company Limited

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SC-560
3-(4-CHLOROPHENYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE

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