HDAC3 is highly expressed in brain, and its activity has been associated with negative regulation of learning and memory processes. RGFP966 is a selective inhibitor of HDAC3 (IC50 = 0.08 μM) that does not affect other HDACs at concentrations up to 15 μM. At 10 mg/kg, RGFP966 can facilitate the extinction of cocaine-seeking behavior and enhance long-term object memory acquisition/consolidation in mice. At 10 μM, RGFP966 can also induce apoptosis of cutaneous T cell lymphoma cells by disrupting their DNA replication activity.
