1357389-11-7

RGFP966 (1357389-11-7) is a selective inhibitor of HDAC3 (IC50?= 80 nM, no other HDACs inhibited @ 15μM).1?It facilitates the extinction of cocaine-seeking behavior in mice and transforms subthreshold learning events into robust long-term memory, suggesting a potential therapeutic target for memory enhancement and neurodegenerative diseases.1-5

(E)-RGFP 966 is a histone deacetylase 3 (HDAC3) inhibitor.

ChEBI: N-(2-amino-4-fluorophenyl)-3-[1-(3-phenylprop-2-enyl)-4-pyrazolyl]-2-propenamide is an aromatic amide and an aromatic amine.

HDAC3

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1) Malvaez?et al.?(2013),?HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner; Proc. Natl. Acad. Sci. USA?110?2647 2) Bieszczad?et al.?(2015),?Histone Deacetylase Inhibition via RGFP966 Releases the Brakes on Sensory Cortical Plasticity and the Specificity of Memory Formation; J. Neurosci.?35?13124 3) Zhu?et al.?(2017),?HDAC3 negatively regulates spatial memory in a mouse model of Alzheimer’s disease; Aging Cell?16?1073 4) Haiqun?et al. (2016),?The Effects of Pharmacological Inhibition of Histone Deacetylase 3 (HDAC3)in Huntington’s Disease Mice; PLoS One 0152498 5) Janczura?et al.?(2018),?Inhibition of HDAC3 reverses Alzheimer’s disease-related pathologies in vitro and in the 3xTg-AD mouse model; Proc. Natl. Acad. Sci. USA?115?E11148