Soluble in dimethyl sulfoxide, ethanol and dimethyl formamide.
form
powder
pka
16.12±0.40(Predicted)
color
white to beige
Stability
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months
Safety Information
Symbol(GHS)
Signal word
Danger
Hazard statements
H301：Toxic if swalloed
H302：Harmful if swallowed
H319：Causes serious eye irritation
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P301+P310：IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313：IF eye irritation persists: Get medical advice/attention.
Description
EX-527 is a potent and selective sirtuin 1 (SIRT1) inhibitor (IC50 38 nM) identified from a high throughput screen. EX-527 is more selective (200-500-fold) for SIRT1 than for SIRT2 or SIRT3 and has been shown to be a potent SIRT6 inhibitor using H3K56 deacetylation site based substrate. EX-527 does not inhibit class I/II HDAC activity at concentrations up to 100uM. Enhances p53 acetylation in response to DNA damaging agents. EX-527 is racemic; the active isomer (EX-243) gives similar results and potency whereas the other isomer (designated EX-242) is inactive.
