KIFUNENSINE

$50 - $1901

Product nameKIFUNENSINE
Cas No109944-15-2
MFC8H12N2O6
MW232.19
MDL NumberMFCD00270017

Synonyms

KIFUNENSINE, KITASATOSPORIA KIFUNENSE;Imidazo1,2-apyridine-2,3-dione, hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-, (5R,6R,7S,8R,8aS)-;FR 900494, Hexahydro-6R,7S,8aS-trihydroxy-5R-(hydroxymethyl)-imidazo[1,2-a] pyridine-2,3-dione;(5R,8aS)-1,5,6,7,8,8a-Hexahydro-6β,7α,8α-trihydroxy-5α-(hydroxymethyl)imidazo[1,2-a]pyridine-2,3-dione;(5R,6R,7S,8R,8aS)-Hexahydro-6,7,8-trihydroxy-5-(hydroxymethyl)-imidazo[1,2-a]pyridine-2,3-dione;[5R-(5α,6β,7α,8α,8aα)]-;Kifunensine min. 99%;FR 900494

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Price

44 prices

Brand less more

Sigma-Aldrich Cayman Chemical Arctom AvaChem Tocris TRC Usbiological ApexBio Technology Axon Medchem Medical Isotopes, Inc. Apolloscientific ChemScene Biosynth
Package less more

25mg 10mm*1mlindmso(solution) 2mg 1 100mg 1mg 5mg 50mg 10mg 10mm*1mlindmso(solid+solvent)

Clear All Done

Brand	Packaging	Price	Product name
ApexBio Technology B7315	1mg	$95	Kifunensine
ApexBio Technology B7315	1mg	$110	Kifunensine
ApexBio Technology B7315	5mg	$349	Kifunensine
ApexBio Technology B7315	10mg	$507	Kifunensine
ApexBio Technology B7315	50mg	$1901	Kifunensine
Apolloscientific BICL4125	25mg	$1047	Kifunensine
Apolloscientific BICL4125	10mg	$517	Kifunensine
Apolloscientific BICL4125	5mg	$322	Kifunensine
Apolloscientific BICL4125	1mg	$218	Kifunensine
Arctom HY-19332	10mM*1mLinDMSO(Solid+Solvent)	$189	Kifunensine

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Properties

Melting point	>280°C
Density	1.85±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	water, double-distilled: soluble50MM
form	White solid
pka	9.61±0.70(Predicted)
color	White
biological source	synthetic (organic)
Water Solubility	Soluble to 5 mM in water with sonication
Stability	Desiccate and Store at -20°C
InChI	1S/C8H12N2O6/c11-1-2-3(12)4(13)5(14)6-9-7(15)8(16)10(2)6/h2-6,11-14H,1H2,(H,9,15)/t2-,3-,4+,5+,6+/m1/s1
InChIKey	OIURYJWYVIAOCW-PQMKYFCFSA-N
SMILES	N21[C@H](NC(=O)C2=O)[C@H]([C@H]([C@@H]([C@H]1CO)O)O)O

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H319：Causes serious eye irritation

Precautionary statements

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313：IF eye irritation persists: Get medical advice/attention.

Description

Kifunensine is an immunoactive compound originally produced by Kitasatosporia kifunense, which displays competitive inhibition against immunosuppressive factor in tumor-bearing mice. Kifunensine has also been shown to be a potent inhibitor of the purified glycoprotein processing enzyme, mannosidase I (MAN1), specifically MAN1A1, MAN1A2, MAN1B1 and MAN1C1. Enzymes of this class are important factors for the biosynthesis of various types of N-linked oligosaccharide structures. Inhibition of these structures by kifunensine can interfere with cell-to-cell adhesion, targeting of lysosomal hydrolases to lysosomes, and clearance of asialoglycoproteins from the serum.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
Shanghai Acmec Biochemical Technology Co., Ltd.
Aladdin Scientific
SHANGHAI KEAN TECHNOLOGY CO., LTD.
Dingyuan (Tianjin) Biomedical Technology Co., LTD
J & K SCIENTIFIC LTD.
3B Pharmachem (Wuhan) International Co.,Ltd.
Chemsky（shanghai）International Co.,Ltd.
Shanghai T&W Pharmaceutical Co., Ltd.

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