3-[[4-(Dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]benzamide;JNK-IN-7;JNK inhibitor;CS-2418;JNK inhibitor 7;Benzamide, 3-[[4-(dimethylamino)-1-oxo-2-buten-1-yl]amino]-N-[4-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]phenyl]-;JNK-IN-7 Only for R&D;(E)-3-(4-(dimethylamino)but-2-enamido)-N-(4-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)phenyl)benzamide
≥24.7 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
form
solid
pka
13.34±0.70(Predicted)
color
White to gray
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H315：Causes skin irritation
H319：Causes serious eye irritation
H335：May cause respiratory irritation
Precautionary statements
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352：IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC50s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC50s = 130 and 244 nM, respectively).
