1408064-71-0

JNK inhibitor VII is a potent and non-selective inhibitor of JNKs (IC₅₀s = 1.54, 1.99, and 0.75 nM for JNK1, -2, and -3, respectively). It inhibits phosphorylation of c-Jun in HeLa and A375 cells (EC₅₀s = 130 and 244 nM, respectively).

JNK Inhibitor IX is a potent and selective inhibitor of JNK2 and JNK3. Neuroresearch & Neuroprotective Product.

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[1]. zhang t, inesta-vaquera f, niepel m et al. discovery of potent and selective covalent inhibitors of jnk. chem biol. 2012 jan 27;19(1):140-54.
[2]. goh et, arthur js, cheung pc et al. identification of the protein kinases that activate the e3 ubiquitin ligase pellino 1 in the innate immune system. biochem j. 2012 jan 1;441(1):339-46.