Ilomastat

$32 - $5661

Product nameIlomastat
Cas No142880-36-2
MFC20H28N4O4
MW388.46
MDL NumberMFCD00917040

Synonyms

(2R)-N4-Hydroxy-N1-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)-butanediamide Ilomastat (GM6001, Galardin);Galardin CS 610;Ilomastat, >=98%;(r)-n4-hydroxy-n1-[(s)-2-(1h-indol-3-yl)-1-methylcarbamoly-ethyl]-2-isobutyl-succinamide;galardin tm;(R)-N4-Hydroxy-N1-[(S)-2-(1H-indol-3-yl)-1-methylcarbamoyl-ethyl]-2-isobutyl-succinamide;Galardin, GM6001, Ilomastat;SANTACRUZ

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Price

40 prices

Brand less more

Alfa Aesar Sigma-Aldrich Cayman Chemical CSNpharm Arctom Chemenu Crysdot TRC Biorbyt Ltd ApexBio Technology Ark Pharm Medical Isotopes, Inc. ChemScene Ambeed DC Chemicals
Package less more

500μg 1mg 2mg 2.5mg 5mg 10mg 50mg 100mg 250mg 1g 1000mg

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Brand	Packaging	Price	Product name
Alfa Aesar J65687	1mg	$81.1	GM 6001
Alfa Aesar J65687		$329.65
Alfa Aesar J65687	5mg	$366	GM 6001
Ambeed A237914	50mg	$407	GM 6001
Ambeed A237914	100mg	$666	GM 6001
Ambeed A237914	2mg	$57	GM 6001
Ambeed A237914	5mg	$74	GM 6001
Ambeed A237914	10mg	$122	GM 6001
Ambeed A237914	1g	$5661	GM 6001
ApexBio Technology A4050	5mg	$100	GM 6001

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Properties

Density	1.228±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	Soluble in DMSO, and 100% ethanol.
pka	9.16±0.20(Predicted)
form	Off-white solid
color	White
Sensitive	Moisture Sensitive
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey	NITYDPDXAAFEIT-DYVFJYSZSA-N

Safety Information

Symbol(GHS)

Signal word

Warning

Hazard statements

H315：Causes skin irritation

H319：Causes serious eye irritation

Precautionary statements

P261：Avoid breathing dust/fume/gas/mist/vapours/spray.

P264：Wash hands thoroughly after handling.

P264：Wash skin thouroughly after handling.

P270：Do not eat, drink or smoke when using this product.

P271：Use only outdoors or in a well-ventilated area.

P280：Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338：IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313：IF SKIN irritation occurs: Get medical advice/attention.

P337+P313：IF eye irritation persists: Get medical advice/attention.

P501：Dispose of contents/container to..…

Description

GM 6001 is a potent, reversible broad spectrum inhibitor of zinc-containing proteases, including matrix metalloproteinases (MMPs). It inhibits zinc-containing thermolysin and elastase from P. aeruginosa, both with Ki values of 20 nM. GM 6001 inhibits MMP-1, -2, -7, -8, -9, -12, -13, -14, -16, and -26 with Ki or IC50 values between 0.1 and 10 nM. It inhibits disintegrin and metalloproteinase domain-containing (ADAM) proteins ADAM9, ADAM10, ADAM12, and ADAM17 at nanomolar concentrations. It less potently inhibits lethal factor from B. anthracis anthrax lethal toxin (Ki = 2.74 μM). GM 6001 also impairs the growth of the human pathogen Chlamydia by inhibiting peptide deformylase, which contains iron rather than zinc (IC50 = 38 nM).

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Suppliers and manufacturers

career henan chemical co

$1.00/100g

Ilomastat

CAS:142880-36-2
TargetMol Chemicals Inc.

$41.00/1mg

Ilomastat

CAS:142880-36-2
ATK CHEMICAL COMPANY LIMITED
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
Shenzhen Excellent Biotech Co., Ltd.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Zhejiang J&C Biological Technology Co.,Limited
Nextpeptide Inc
Alfa Chemistry

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Ilomastat

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