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Description
Fenamidone (13; RPA 407213; (S)-5-methyl-2-methylthio-
5-phenyl-3-phenylamino-3,4-dihydroimidazol-4-one) is a complex III inhibitor
that does not derive from the strobilurins but rather
belongs to the imidazolinone chemical class. Fenamidone is a white woolly powder, with the
following characteristics: mp = 137 ?C; water solubility =
7.8 mg/L; logP = 2.8, and vp = 3.4×10?7 Pa. It was
first described by Mercer et al. (39) in 1998. Only the
S-enantiomer shows antifungal activity, thus offering a
reduction in application rates over the racemic mixture.