Coumatetralyl, is also called 4-hydroxy-3-(1,2,3,4-
tetrahydro-1-naphthyl)coumarin, consists of colorless crystals which are
slightly soluble in water (pH 7), benzene, toluene, diethyl
ether, readily soluble in dimethylformamide, dichloromethane,
isopropanol, soluble in alcohols, acetone.
Coumatetralyl is produced by the condensation of 4-
hydroxycoumarin with 1,2,3,4-tetrahydro-1-naphthol (28).
First introduced in 1956, coumatetralyl is one of the
most widely used first-generation anticoagulants. It is not,
however, available in the United States.
