General Description
Yellowish-white crystalline powder; colorless when pure; odorless. This material is used as a rodenticide, functioning as an anticoagulant that does not induce bait-shyness.
Reactivity Profile
Ketones, such as COUMATETRALYL, are reactive with many acids and bases liberating heat and flammable gases (e.g., H2). The amount of heat may be sufficient to start a fire in the unreacted portion of the ketone. Ketones react with reducing agents such as hydrides, alkali metals, and nitrides to produce flammable gas (H2) and heat. Ketones are incompatible with isocyanates, aldehydes, cyanides, peroxides, and anhydrides. They react violently with aldehydes, HNO3, HNO3 + H2O2, and HClO4.
Health Hazard
Overdosage with anticoagulants may cause acute bleeding. Pre-existing blood clotting disease or liver disease may be aggravated by exposure.
Potential Exposure
Coumatetralyl is used as a rodenticide, functioning as an anticoagulant that does not induce baitshyness.
Fire Hazard
(Non-Specific--Coumarin Derivative Pesticide, Solid, n.o.s.) This material may burn but does not ignite readily. Fire and runoff from fire control water may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Container may explode in heat of fire. Enolic form of compound has acidic properties and can form salts with metals.
First aid
If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Speed in removing material from skin is of extreme importance. Shampoo hair promptly if contaminated. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Medical observation is recommended for 2436 hours following overexposure, as effects may be delayed.
Shipping
UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Incompatibilities
Contact with oxidizers may cause fire and explosion hazard. Keep away from metals.
Description
Coumatetralyl, is also called 4-hydroxy-3-(1,2,3,4-
tetrahydro-1-naphthyl)coumarin, consists of colorless crystals which are
slightly soluble in water (pH 7), benzene, toluene, diethyl
ether, readily soluble in dimethylformamide, dichloromethane,
isopropanol, soluble in alcohols, acetone.
Coumatetralyl is produced by the condensation of 4-
hydroxycoumarin with 1,2,3,4-tetrahydro-1-naphthol (28).
First introduced in 1956, coumatetralyl is one of the
most widely used first-generation anticoagulants. It is not,
however, available in the United States.
Chemical Properties
Coumatetralyl is a yellowish-white, crystalline solid.
Waste Disposal
Dissolve in a solvent and burn in a furnace by spraying in the solution
Uses
Coumatetralyl is used as an anticoagulant rodenticide. Coumatetralyl is widely used to control rodent populations.
Definition
ChEBI: Coumatetralyl is a hydroxycoumarin.
Production Methods
Coumatetralyl is commercially synthesised through a condensation reaction between 4-hydroxycoumarin and 1-tetralonyl ketone. This process typically occurs in the presence of a base such as sodium hydroxide and a solvent like ethanol or acetic acid under controlled temperature conditions. The reaction yields coumatetralyl, which is then purified through crystallisation and drying to produce a stable, active compound.
Agricultural Uses
Rodenticide: Coumatetralyl is used for rat control and functions
as an anticoagulant, of the warfarin type, that does not induce bait-shyness. Not approved for use in EU countries or
the U.S. There are 17 global suppliers.
Trade name
BAY® 25634; BAY ENE® 11183B;
BAYER® 25,634; ENDOX®; ENDROCID®;
ENDROCIDE®; RACUMIN®; RAUCUMIN® 57;
RODENTIN®
Mechanism of action
1st generation anticoagulant, blocks formation of prothrombin, inhibits blood coagulation causing death by internal haemorrhage
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area away from oxidizers
Toxicity evaluation
The acute toxicity
for Norway rats is given as high but, as with many of these compounds, coumatetralyl is more potent when administered
in consecutive daily doses. No satisfactory data are
available on the acute oral toxicity of the compound to mice.
However, a complete kill of mice was obtained in the laboratory
following 21 days of feeding on coumatetralyl bait (29).
Proprietary baits generally carry 0.375% coumatetralyl.
Powder concentrates are available (strength 0.75%) which
are used for the preparation of poisoned baits and as a
tracking dust (18).
Pesticide Type
Rodenticide
