Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt)

Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) (Aβ40; Item No. 21617) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer’s disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1WARNING This product is not for human or veterinary use.