Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt)

Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) (Aβ40; Item No. 21617) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer’s disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1WARNING This product is not for human or veterinary use.

[1] HEINKE SCHIEB. Beta-amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice: comparison with human Alzheimer amyloid.[J]. The Journal of Biological Chemistry, 2011, 286 39: 33747-33758. DOI: 10.1074/jbc.m111.246561
[2] SADIM JAWHAR  Thomas A B  Oliver Wirths. Pyroglutamate amyloid-β (Aβ): a hatchet man in Alzheimer disease.[J]. The Journal of Biological Chemistry, 2011, 286 45: 38825-38832. DOI: 10.1074/jbc.r111.288308