Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt)

Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.1 It has been found in postmortem cerebral cortex from patients with Alzheimer’s disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down’s syndrome.2,3 In vitro, Aβ (17-42) forms amorphous aggregates that bind less thioflavin T than Aβ (1-40) (Item No. 21617) and Aβ (1-42) (Item No. 20574).3 It is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells when used at a concentration of 20 μM.1WARNING This product is not for human or veterinary use.

[1] WEI W, NORTON D, WANG X, et al. Abeta 17-42 in Alzheimer’s disease activates JNK and caspase-8 leading to neuronal apoptosis.[J]. Brain : a journal of neurology, 2002, 1 1: 0. DOI: 10.1093/brain/awf205
[2] E GOWING. Chemical characterization of A beta 17-42 peptide, a component of diffuse amyloid deposits of Alzheimer disease.[J]. The Journal of Biological Chemistry, 1994, 269 15: 10987-10990.
[3] M LALOWSKI. The “nonamyloidogenic” p3 fragment (amyloid beta17-42) is a major constituent of Down’s syndrome cerebellar preamyloid.[J]. The Journal of Biological Chemistry, 1996, 271 52: 33623-33631. DOI: 10.1074/jbc.271.52.33623