Amyloid-β (17-42) Peptide (human) (trifluoroacetate salt)

Amyloid-β (Aβ) (17-42) is a 26-residue fragment of the Aβ protein that is formed via post-translational processing of amyloid precursor protein (APP) by α- and γ-secretases.1 It has been found in postmortem cerebral cortex from patients with Alzheimer’s disease that have diffuse amyloid plaques and in cerebellar preamyloid lesions in patients with Down’s syndrome.2,3 In vitro, Aβ (17-42) forms amorphous aggregates that bind less thioflavin T than Aβ (1-40) (Item No. 21617) and Aβ (1-42) (Item No. 20574).3 It is cytotoxic to SH-SY5Y and IMR-32 cells in a concentration-dependent manner and induces cleavage of caspase-3 and poly(ADP-ribose) polymerase (PARP) in SH-SY5Y cells when used at a concentration of 20 μM.1WARNING This product is not for human or veterinary use.