GPR31, also known as the 12(S)-HETE receptor (12-HETER), is a G protein-coupled receptor that is coupled to the Gi signal transduction pathway and activated by 12(S)-HETE (Item No. 34570), a metabolite of arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607).1,2 It is expressed by platelets and localizes to the plasma membrane and endoplasmic reticulum.1,3 siRNA knockdown of GPR31 inhibits 12(S)-HETE-induced tumor cell invasion in vitro, and Gpr31 knockdown in murine Hepa1-6 cells reduces tumorigenesis of those cells in a mouse model of hepatocellular carcinoma recurrence after hepatic ischemia-reperfusion injury.2,4 It is overexpressed in prostate cancer tumors and positively correlated with tumor grade.5 Cayman's GPR31 (N-Term) Polyclonal Antibody can be used for ELISA, flow cytometry (FC), and immunofluorescence (IF) applications. The antibody recognizes the N-terminal region of GPR31 from human samples.WARNING This product is not for human or veterinary use.
