GPR41 is a G protein-coupled receptor activated by short chain fatty acids (SCFAs).1,2,3 Several SCFAs have the potential to bind and activate GPR41, with pentanoate being the most potent agonist.2 GPR41 couples through the Pertussis toxin-sensitive Gi/o family and its expression has been described in adipose tissue and the colonic lumen.3,2,1 The activation of GPR41 induces an increase in intracellular Ca2+, ERK1/2 activation and a decrease in intracellular cAMP.3,2,1 Activation of GPR41 may be involved in intestinal inflammation. The predicted size for GPR41 is 39 kDa. Cayman’s GPR41 (N-Term) Polyclonal Antibody detects a 43 kDa band by western blot in cell lysates.WARNING This product is not for human or veterinary use.
