Bupropion hydrochloride, an aminoketone structurally unrelated to tricyclics or
tetracyclics, is a dopamine uptake blocker with antidepressant activity. Its clinical
efficacy is reportedly comparable to that of amitriptyline, yet unlike most conventional
antidepressants, bupropion hydrochloride is not associated with orthostatic hypotension or
other cardiovascular side-effects.
