Stable for 2 years from date of purchase as supplied. Solution in DMSO may be stored at -20°C for up to 3 months.
Safety Information
Symbol(GHS)
Signal word
Warning
Hazard statements
H302：Harmful if swallowed
H400：Very toxic to aquatic life
Precautionary statements
P264：Wash hands thoroughly after handling.
P264：Wash skin thouroughly after handling.
P270：Do not eat, drink or smoke when using this product.
P273：Avoid release to the environment.
P301+P312：IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330：Rinse mouth.
P391：Collect spillage. Hazardous to the aquatic environment
P501：Dispose of contents/container to..…
Description
CGP 37157 is a benzothiazepine that acts as a selective inhibitor of the mitochondrial sodium-calcium exchanger (IC50 = 0.36 μM in isolated mitochondria). It does not affect channels, exchangers, or ATPases on the cardiac sarcolemma or ATPases on sarcoplasmic reticulum. CGP 37157 is commonly used to study the role of mitochondrial-derived calcium in cytoplasmic calcium homeostasis. CGP 37157 inhibits sodium-dependent calcium efflux via the mitochondrial exchanger NCLX in a variety of cell types (IC50 = 5 μM).
