PAMAM dendrimer G5.5 carboxylate (PAMAM G5.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro.1 It is approximately 103.9 Å in diameter in water and has 192 surface groups.2 Unlike PAMAM dendrimer G3.0 amine (Item No. 39073), PAMAM G5.5 carboxylate (100 µg/ml) does not induce cytotoxicity or autophagy in A549 cells.3 Bimetallic nanoparticles of PAMAM G5.5 carboxylate with gold and platinum scavenge DPPH (Item No. 14805) radicals in a cell-free assay.4 Complexes of PAMAM G5.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 1.48 µM).1WARNING This product is not for human or veterinary use.
