pamam dendrimer, generation 4.5 solution

PAMAM dendrimer G4.5 carboxylate (PAMAM G4.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system.1 It is approximately 87.9 Å in diameter in water and has 96 surface groups.2 Unlike the amine-terminated PAMAM G5.0 (Item No. 39075), it does not rupture bilayer lipid membranes when used at a concentration of 50 µM.3 PAMAM G4.5 carboxylate disulfur-linked aggregates (10 µg/ml) encapsulating the phenol ferulic acid (Item No. 19871) and the mitotic inhibitor paclitaxel (Item No. 10461) induce apoptosis and decrease the mitochondrial membrane potential in multidrug-resistant KB-8-5 epidermal carcinoma cells.1 Complexes of PAMAM G4.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 620 nM).4 A fluorescently labeled form of PAMAM G4.5 carboxylate selectively accumulates in tumors and kidneys over liver, spleen, heart, and lungs in a 4T1 murine mammary carcinoma model.5WARNING This product is not for human or veterinary use.