PAMAM dendrimer generation 5.5

PAMAM dendrimer G5.5 carboxylate (PAMAM G5.5 carboxylate) is a polyamidoamine (PAMAM) dendrimer with carboxylate termini that has been used as a drug delivery system in vitro.1 It is approximately 103.9 Å in diameter in water and has 192 surface groups.2 Unlike PAMAM dendrimer G3.0 amine (Item No. 39073), PAMAM G5.5 carboxylate (100 µg/ml) does not induce cytotoxicity or autophagy in A549 cells.3 Bimetallic nanoparticles of PAMAM G5.5 carboxylate with gold and platinum scavenge DPPH (Item No. 14805) radicals in a cell-free assay.4 Complexes of PAMAM G5.5 carboxylate with the active component of cisplatin are cytotoxic to A2780 ovarian cancer cells (IC50 = 1.48 µM).1WARNING This product is not for human or veterinary use.

[1] GORDON J. KIRKPATRICK . Evaluation of anionic half generation 3.5–6.5 poly(amidoamine) dendrimers as delivery vehicles for the active component of the anticancer drug cisplatin[J]. Journal of Inorganic Biochemistry, 2011, 105 9: Pages 1115-1122. DOI: 10.1016/j.jinorgbio.2011.05.017
[2] GABRIELLA CAMINATI  Donald A T  Nicholas J Turro. Photophysical investigation of starburst dendrimers and their interactions with anionic and cationic surfactants[J]. Journal of the American Chemical Society, 1990, 112 23: 8515-8522. DOI: 10.1021/ja00179a041
[3] CHENGGANG LI. PAMAM nanoparticles promote acute lung injury by inducing autophagic cell death through the Akt-TSC2-mTOR signaling pathway.[J]. Journal of Molecular Cell Biology, 2009, 1 1: 37-45. DOI: 10.1093/jmcb/mjp002
[4] TAKESHI ENDO. Scavenging DPPH radicals catalyzed by binary noble metal–dendrimer nanocomposites[J]. Journal of Colloid and Interface Science, 2006, 302 2: Pages 516-521. DOI: 10.1016/j.jcis.2006.06.053