Glucagon-like peptide 1 (GLP-1) (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption. It binds the GLP-1 receptor (pIC50 = 8.5) in the pancreas and displays various antidiabetic effects by potentiating glucose-induced secretion of insulin from pancreatic β-cells, increasing insulin expression, inhibiting β-cell apoptosis, promoting β-cell neogenesis, reducing glucagon secretion, delaying gastric emptying, promoting satiety, and increasing peripheral glucose disposal.
