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ChemicalBook >> CAS DataBase List >>Pyrazinamide

Pyrazinamide suppliers

Pyrazinamide

CAS:: 98-96-4

MF:: C5H5N3O

MW:: 123.11

SecurityInformation

Symbol(GHS) ：: GHS07

Signal word ：: Warning

Hazard statements ：: H315-H319-H335

Precautionary statements ：: P261-P271-P280

Hazard Codes ：: F,C

Risk Statements ：: 11-34

Safety Statements ：: 22-24/25-45-36/37/39-26-16

WGK Germany ：: 3

RTECS ：: UQ2275000

TSCA ：: TSCA listed

HS Code ：: 29339990

Storage Class：: 11 - Combustible Solids

Hazardous Substances Data：: 98-96-4(Hazardous Substances Data)

Toxicity：: LD50 intraperitoneal in mouse: 1680mg/kg

Use：: Pyrazinecarboxamide (PZA) occurs as a white crystalline powder that is sparingly soluble in water and slightly soluble in polar organic solvents. Its antitubercular properties were discovered as a result of an investigation of heterocyclic analogs of nicotinic acid, with which it is isosteric. Pyrazinamide has recently been elevated to first-line status in short-term tuberculosis treatment regimens because of its tuberculocidal activity and comparatively low short-term toxicity. Since pyrazinamide is not active against metabolically inactive tubercle bacilli, it is not considered suitable for long-term therapy. Potential hepatotoxicity also obviates long-term use of the drug. Pyrazinamide is maximally effective in the low pH environment that exists in macrophages (monocytes). Evidence suggests bioactivation of pyrazinamide to pyrazinoic acid by an amidase present in mycobacteria.

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You can find Pyrazinamide suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

Wuhan Fortuna Chemical Co., Ltd