Cefpodoxime

한글명:Cefpodoxime

카스 번호80210-62-4

상품명:Cefpodoxime

CBNumberCB9511604

분자식C15H17N5O6S2

포뮬러 무게427.46

MOL 파일80210-62-4.mol

화학적 성질

녹는점	200-202°C
밀도	1.78±0.1 g/cm3(Predicted)
RTECS 번호	XI0367365
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	DMSO에 용해됨
산도 계수 (pKa)	2.77±0.50(Predicted)
물리적 상태	Solid
색상	White to off-white
감도	Light Sensitive
BRN	6021381
안정성	흡습성

위험 및 안전 성명

위험품 표기	Xn
위험 카페고리 넘버	42/43
안전지침서	22-36/37-45
WGK 독일	3

그림문자(GHS)

Cefpodoxime 화학적 특성, 용도, 생산

화학적 성질
Off-White Solid
용도
A metabolite of Cefpodoxime Proxetil. An antibacterial.
정의
ChEBI: A third-generation cephalosporin antibiotic with methoxymethyl and (2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetamino substituents at positions 3 and 7, respectively, of the cephem skeleton. Given by mouth as its proxetil ester prodrug, it is used to treat acute otitis media, pharyngitis, and sinusitis.
Antimicrobial activity
It is stable to a wide range of plasmid-mediated β-lactamases. It induces the chromosomal β-lactamases of Ps. aeruginosa, Enterobacter spp., S. marcescens and Citrobacter spp., but is a less potent inducer than cefoxitin.
Pharmacokinetics
Oral absorption: c. 50%
C_max 200 mg oral: 2.1 mg/L after 3 h
Plasma half-life: c. 2.2 h
Volume of distribution: c. 35 L
Plasma protein binding: 20–30%
Absorption and distribution
The ester is rapidly hydrolyzed to the parent compound in the small intestine. Bioavailability increases to 65% if taken with food, but antacids and H2-receptor antagonists reduce absorption. Unabsorbed drug is hydrolyzed and excreted in the feces.
It is well distributed and penetrates well into tissues (including lung tissue) and inflammatory exudate to achieve concentrations inhibitory to common pathogens.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Metabolism and excretion
The hydrolyzed prodrug is not subject to further metabolism. About 80% of the absorbed compound (30–40% of the original dose) appears in the urine over 24 h. Excretion is by glomerular filtration and tubular secretion; probenecid delays secretion and increases the peak plasma concentration.
Clinical Use
Cefpodoxime has been used principally for the treatment of upper and lower respiratory tract infections in children and adults.
부작용
The drug is well tolerated, but gastrointestinal disturbance with diarrhea is common. Pseudomembranous colitis has been reported occasionally. Other side effects are those common to cephalosporins.

Cefpodoxime 준비 용품 및 원자재

Cefpodoxime 공급 업체

Cefpodoxime 관련 검색

Send Inquriy