프로판디올(S-1,2)

한글명:프로판디올(S-1,2)

카스 번호4254-15-3

상품명:(S)-(+)-1,2-Propanediol

CBNumberCB9145670

분자식C3H8O2

포뮬러 무게76.09

MOL 파일4254-15-3.mol

동의어(한글)

(S)-(+)-프로필렌글리콜

프로판디올(S-1,2)

(S)-(\+)-프로필렌 글리콜

화학적 성질

녹는점	-59 °C
알파	16 º (c=neat)
끓는 점	186-188 °C765 mm Hg(lit.)
밀도	1.036 g/mL at 20 °C(lit.)
굴절률	n20/D 1.432(lit.)
인화점	225 °F
저장 조건	Keep in dark place,Sealed in dry,Room Temperature
용해도	Miscible with acetone, chloroform, ethanol (95%), glycerin, and water; soluble at 1 in 6 parts of ether; not miscible with light mineral oil or fixed oils, but will dissolve some essential oils.
산도 계수 (pKa)	14.49±0.20(Predicted)
물리적 상태	액체
색상	무색의
Specific Gravity	1.04
optical activity	[α]20/D +16.5°, neat
폭발한계	2.6-12.6%(V)
수용성	녹는
감도	Hygroscopic
Merck	14,7855
BRN	1718871
안정성	휘발성 물질
CAS 데이터베이스	4254-15-3(CAS DataBase Reference)
NIST	(S)-(+)-1,2-Propanediol(4254-15-3)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38-22

안전지침서

24/25-36/37/39-26

WGK 독일

HS 번호

29053200

NFPA 704:

	1
0		1

그림문자(GHS)

프로판디올(S-1,2) 화학적 특성, 용도, 생산

화학적 성질
Colorless to light yellow liqui
용도
(S)-(+)-1,2-Propanediol acts as an organic solvent and diluent used in pharmaceutical preparations. It is also used as a chiral synthetic intermediate and substrate for enzyme studies.
생산 방법
Propylene is converted to chlorohydrin by chlorine water and hydrolyzed to 1,2-propylene oxide. With further hydrolysis, 1,2- propylene oxide is converted to propylene glycol.
Pharmaceutical Applications
Propylene glycol has become widely used as a solvent, extractant, and preservative in a variety of parenteral and nonparenteral pharmaceutical formulations. It is a better general solvent than glycerin and dissolves a wide variety of materials, such as corticosteroids, phenols, sulfa drugs, barbiturates, vitamins (A and D), most alkaloids, and many local anesthetics.
As an antiseptic it is similar to ethanol, and against molds it is similar to glycerin and only slightly less effective than ethanol. Propylene glycol is commonly used as a plasticizer in aqueous film-coating formulations.
Propylene glycol is also used in cosmetics and in the food industry as a carrier for emulsifiers and as a vehicle for flavors in preference to ethanol, since its lack of volatility provides a more uniform flavor.
저장
At cool temperatures, propylene glycol is stable in a well-closed container, but at high temperatures, in the open, it tends to oxidize, giving rise to products such as propionaldehyde, lactic acid, pyruvic acid, and acetic acid. Propylene glycol is chemically stable when mixed with ethanol (95%), glycerin, or water; aqueous solutions may be sterilized by autoclaving.
Propylene glycol is hygroscopic and should be stored in a wellclosed container, protected from light, in a cool, dry place.
비 호환성
Propylene glycol is incompatible with oxidizing reagents such as potassium permanganate.
Regulatory Status
GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (dental preparations; IM and IV injections; inhalations; ophthalmic, oral, otic, percutaneous, rectal, topical, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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