1-벤질-4-피페리돈

한글명:1-벤질-4-피페리돈

카스 번호3612-20-2

상품명:1-Benzyl-4-piperidone

CBNumberCB8341198

분자식C12H15NO

포뮬러 무게189.25

MOL 파일3612-20-2.mol

동의어(한글)

1-벤질-4-피페리돈

N-벤질-4-피페리돈

화학적 성질

끓는 점	134 °C7 mm Hg(lit.)
밀도	1.021 g/mL at 25 °C(lit.)
증기압	0.079-0.15Pa at 20-25℃
굴절률	n20/D 1.541(lit.)
인화점	>230 °F
저장 조건	2-8°C
용해도	12g/L
물리적 상태	기름진 액체
산도 계수 (pKa)	7.07±0.20(Predicted)
Specific Gravity	1.021
색상	무색투명~연노랑
수용성	12g/L(20℃)
BRN	128556
LogP	2.1 at 20℃ and pH9
CAS 데이터베이스	3612-20-2(CAS DataBase Reference)
NIST	4-Piperidinone, 1-(phenylmethyl)-(3612-20-2)

위험 및 안전 성명

위험품 표기

Xi,Xn

위험 카페고리 넘버

36/37/38-43-22-20/21/22

안전지침서

26-36-37/39

WGK 독일

위험 참고 사항

Irritant

HS 번호

29333999

NFPA 704:

	2
2		0

그림문자(GHS)

1-벤질-4-피페리돈 MSDS

1-벤질-4-피페리돈 화학적 특성, 용도, 생산

화학적 성질
Clear colorless to straw coloured oily liquid
용도
A substituted piperidine as pesticide
화학 반응
As an important organic compound, N-Benzyl-4-piperidone could be used to synthesize many organic compounds. There are four ways to synthesize 1-benzylpiperidine-4-carbaldehyde using it as the raw material. The first method involves the Wittig reaction of (methoxymethyl) triphenylphosphonium chloride with N-benzyl-4-piperidone, followed by hydrolysis of the resulting enol ether. In another method, trimethylsilyl diazomethane is condensed with N-benzyl-4-piperidone, followed by hydrolysis to obtain the final product. In a third route, N-benzyl-4-piperidone is treated with trimethyloxosulfonium iodide to produce the corresponding epoxide. The epoxide is then rearranged in the presence of magnesium bromide etherate, resulting in 1-benzylpiperidine-4-carbaldehyde with high yields. In 2007, a patent described the Darzens condensation of N-benzyl-4-piperidone with ethyl chloroacetate, followed by decarboxylation[1].
Synthesis
1-Benzyl-4-piperidone was synthesized with benzylamine and methyl acrylate as raw materials via 1,4-addition, Dieckmann condensation and hydrolysis decarboxylafion reactions. Add 150 mL of anhydrous toluene and 2.8 g of metallic sodium to a 250 mL dry three-necked flask, stir and heat to reflux. Add 1 mL of anhydrous methanol, then slowly drop 28 g of N.N-bis(β-propionate methyl ester) benzylamine. After adding N.N-bis(β-propionate methyl ester), benzylamine is completed, reflux for 6 h. During the reflux process, the stirring speed needs to be increased, and 100 ml of anhydrous toluene is added to the reaction vessel in batches. Stop reflux, cool to room temperature, extract the mixture with 150 mL of 25% (mass fraction) hydrochloric acid solution, and reflux in an oil bath for 5 h until there is no colour change in the FeCl3 solution test, indicating that the reaction is over. Cool the reaction mixture, add 35% NaOH solution while stirring to neutralize to about pH=8.5, extract with ethyl acetate (100 ml×3), combine the ethyl acetate layers, wash with saturated NaCl solution, and dry over anhydrous magnesium sulfate. Ethyl acetate was recovered by distillation, and the remaining material was distilled under reduced pressure to obtain 14.8 g of 1-benzyl-4-piperidone with a yield of 78.4%. The product was a light yellow oily liquid.
Purification Methods
If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.]

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