트레할로스

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H315：피부에 자극을 일으킴

  H319：눈에 심한 자극을 일으킴

  H335：호흡 자극성을 일으킬 수 있음

• 예방조치문구

  P261：분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

트레할로스 화학적 특성, 용도, 생산

• 화학적 성질

  Trehalose occurs as virtually odorless, white or almost white crystals with a sweet taste (approximately 45% of the sweetness of sucrose).

• 용도

  trehalose is a humectant and moisturizer, it helps bind water in the skin and increase the skin’s moisture content. It is a naturally occurring plant sugar.

• 정의

  ChEBI: A trehalose in which both glucose residues have alpha-configuration at the anomeric carbon.

• 생산 방법

  Trehalose is prepared from liquefied starch by a multistep enzymatic process. The commercial product is the dihydrate.

• Pharmaceutical Applications

  Trehalose is used for the lyoprotection of therapeutic proteins, particularly for parenteral administration. Other pharmaceutically relevant applications include use as an excipient for diagnostic assay tablets; for stabilization during the freeze–thaw and lyophilization of liposomes; and for stabilization of blood cells, cosmetics, and monoclonal antibodies. Trehalose may also be used in formulations for topical application.

• Safety

  Trehalose is used in cosmetics, foods, and parenteral and nonparenteral pharmaceutical formulations. It is generally regarded as a relatively nontoxic and nonirritant material when used as an excipient.
  In the gut, trehalose is rapidly metabolized to glucose by the specific enzyme trehalase. A small minority of the population exhibits a primary (hereditary) or secondary (acquired) trehalase deficiency and thus may experience intestinal discomfort after ingestion of excessive amounts of trehalose owing to the osmotic activity of undigested trehalose in the gut. However, smaller amounts of trehalose are tolerated by such individuals without any symptoms.
  Trehalose is used as a sweetener and is reported to have substantially less cariogenic potential than sucrose.
  LD50 (dog, IV): >1 g/kg
  LD50 (dog, oral): >5 g/kg
  LD50 (mouse, IV): >1 g/kg
  LD50 (mouse, oral): >5 g/kg
  LD50 (rat, IV): >1 g/kg
  LD50 (rat, oral): >5 g/kg

• 저장

  Trehalose is a relatively stable material. At 60°C for 5 hours it loses not more than 1.5% w/w of water (the dihydrate water of crystallization is retained). Open stored powder may liquefy at high relative humidity (≥90%).
  Trehalose should be stored in a cool, dry place in a well-sealed container.

• 비 호환성

  Trehalose is incompatible with strong oxidizing agents, especially in the presence of heat.

• Regulatory Status

  GRAS listed. In the UK trehalose may be used in certain food applications. Included in parenteral and nonparenteral investigational formulations.

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