규산 마그네슘

그림문자(GHS)

규산 마그네슘 화학적 특성, 용도, 생산

• 화학적 성질

  The USP 32 describes magnesium trisilicate as a compound of magnesium oxide and silicon dioxide with varying proportions of water. It contains not less than 20.0% of magnesium oxide and not less than 45.0% of silicon dioxide. The PhEur 6.0 similarly describes magnesium trisilicate as having a variable composition corresponding to the approximate formula Mg₂Si₃O₈·xH₂O. It contains not less than 29.0% of magnesium oxide and not less than the equivalent of 65.0% of silicon dioxide, both calculated with reference to the ignited substance.
  Magnesium trisilicate occurs as an odorless and tasteless, fine, white-colored powder that is free from grittiness.

• 용도

  Industrial odor absorbent, decolorizing agent, antioxidant, medicine (antacid).

• 정의

  USP specifies not less than 20% magnesium oxide and 45% SiO2, similar to the FCC requirements for magnesium silicate. See talc.

• 생산 방법

  Magnesium trisilicate may be prepared from sodium silicate and magnesium sulfate. It also occurs in nature as the minerals meerschaum, parasepiolite, and sepiolite.

• Pharmaceutical Applications

  Magnesium trisilicate is used in oral pharmaceutical formulations and food products as a glidant. It is also used therapeutically as an antacid, and also for the treatment of ciprofloxacin overdose or toxicity.

• Safety

  Magnesium trisilicate is used in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material.
  When administered orally, magnesium trisilicate is neutralized in the stomach to form magnesium chloride and silicon dioxide; some magnesium may be absorbed. Caution should be used when concentrations greater than 50 mEq of magnesium are given daily to persons with impaired renal function, owing to the risk of hypermagnesemia.
  Therapeutically, up to about 2 g of magnesium trisilicate may be taken daily as an antacid. Reported adverse effects include the potential for osmotic diarrhea in the elderly using antacids containing magnesium trisilicate;and the potential for the formation of bladder and renal calculi following the long-term use of magnesium trisilicate as an antacid.

• 저장

  Magnesium trisilicate is stable if stored in a well-closed container in a cool, dry place.

• 비 호환성

  Magnesium trisilicate, when taken with drugs such as mebeverine hydrochloride,proguanil,norfloxacin,sucralfate, and tetracycline, may cause a reduction in bioavailability via binding or chelation. The dissolution rate of folic acid, erythromycin stearate,paracetamol, and chloroquine phosphate may be retarded by adsorption onto magnesium trisilicate. Antimicrobial preservatives, such as the parabens, may be inactivated by the addition of magnesium trisilicate.
  Magnesium trisilicate is also readily decomposed by mineral acids.

• Regulatory Status

  GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (oral tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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