Cefditoren pivoxil

한글명:Cefditoren pivoxil

카스 번호117467-28-4

상품명:Cefditoren pivoxil

CBNumberCB7377697

분자식C25H28N6O7S3

포뮬러 무게620.72

MOL 파일117467-28-4.mol

화학적 성질

녹는점	207-209°C
알파	D20 -48.5° (c = 0.5 in methanol)
밀도	1.55±0.1 g/cm3(Predicted)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	DMSO(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨, 가열)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	8.08±0.60(Predicted)
색상	황백색에서 연한 노란색
Merck	14,1921
CAS 데이터베이스	117467-28-4(CAS DataBase Reference)

위험 및 안전 성명

RTECS 번호	XI0367800
HS 번호	2941.90.3000

그림문자(GHS)

Cefditoren pivoxil 화학적 특성, 용도, 생산

개요
Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.
화학적 성질
Off-White Powder
용도
Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.
정의
ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.
Antimicrobial activity
It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.
Pharmacokinetics
Oral absorption: c. 70%
C_{max 200 mg oral: c. 1.8 mg/L after 1.5–3 h

Plasma half-life: 0.8–1.3 h

Volume of distribution: 9.3 L

Plasma protein binding: 88%

After oral administration the pivaloyl ester is rapidly cleaved
by esterases in the gut wall. Ingestion with food improves
the bioavailability. Plasma concentrations are raised in
elderly patients. There is no accumulation on repeated
dosing.

It is excreted unchanged in the urine with a half-life of
around 1.5 h, achieving a concentration of 150–200 mg/L
within 4 h. Dosage adjustment is recommended in patients
with deteriorating renal function.}
Clinical Use
It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.
부작용
In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.

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