옥시디메톤-메틸

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H400：수생생물에 매우 유독함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P301+P310：삼켰다면 즉시 의료기관(의사)의 진찰을 받으시오.

  P312：불편함을 느끼면 의료기관(의사)의 진찰을 받으시오.

옥시디메톤-메틸 화학적 특성, 용도, 생산

• 개요

  Oxydemeton-methyl, i.e., demeton-S-methyl sulfoxide, is a colorless oil, bp 106 ?C/0.01 mm Hg, vp 3.8 mPa (20 ?C). It is miscible with water and soluble in most organic solvents, except petroleum ether. Log Kow = ?0.74(21 ?C). Oxydemeton-methyl is relatively stable in acidic media but hydrolyzed in alkalinemedia;DT₅₀ values (22 ?C) at pH 4, 7, and 9 are 107, 46, and 2 d, respectively.

• 화학적 성질

  Oxydemeton methyl is a colorless to amber-colored liquid. Oxydemeton methyl is relatively slowly hydrolyzed in acidic media, but rapidly hydrolyzed in alkaline media.
  Oxydemeton methyl is miscible with water; readily soluble (10–100 g/ 100 mL) in dichloromethane, 2-propanol, and toluene; and practically insoluble (＜1 g/100 mL) in n-hexane.

• 용도

  Oxydemeton-methyl is used to control sucking insects on fruit, vines, vegetables, cereals and ornamentals.

• 일반 설명

  Clear amber liquid.

• 공기와 물의 반응

  Water soluble. DEMETON-S-METHYL SULFOXIDE may be rapidly hydrolyzed by alkali .

• 반응 프로필

  Organophosphates such as DEMETON-S-METHYL SULFOXIDE are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.

• 화재위험

  DEMETON-S-METHYL SULFOXIDE is flammable.

• Safety Profile

  Poison by ingestion, skin contact, intravenous, and intraperitoneal routes. Human mutation data reported. When heated to decomposition it emits very toxic fumes of POx and SOx. See also other demeton entries.

• 환경귀착

  Soil. The sulfoxide group is oxidized to the sulfone and oxidative and hydrolytic cleavage of the side chain gives dimethylphosphoric and phosphoric acids (Hartley and Kidd, 1987). Oxamyl was degraded by the microorganism Pseudomonas putida in a laboratory study using cultured bacteria (Zeigler, 1980).
  Plant. In asparagus, oxydemeton-methyl was converted to the corresponding sulfone (Szeto and Brown, 1982).
  Chemical/Physical. Oxydemeton-methyl can be converted to the corresponding sulfone by hydrogen peroxide (Cremlyn, 1991). Emits toxic fumes of phosphorus and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

• 신진 대사 경로

  Oxydemeton-methyl is the primary thiooxidation metabolite of demeton- S-methyl. It is further oxidised rapidly to demeton-Smethylsulfon in all media. The major route of further metabolism of both sulfoxide and sulfone is via hydrolysis to the sulfoxide and sulfone thiols. Stage I1 metabolism of these thiol hydrolysis products proceeds via oxidation and conjugation and is different in soil, plants and animals. In plants the thiols are conjugated, whereas in animals they are mainly methylated and oxidised to sulfoxides, sulfones and sulfonic acids. Demethylation is an important route in mammals; however, the compound is sufficiently polar for much to be excreted in the urine unchanged. Demethylation has also been reported to occur in plants.

• 신진 대사

  Almost 99% of orally administered oxydemeton-methyl to animals is excreted within 48 h in the urine. It is oxidized to the sulfone, followed by hydrolytic cleavage of the P?S bond. The thiol metabolites are conjugated or methylated. O-Demethylation is also an important degradation route both inmammals and plants. Oxydemeton-methyl is rapidly degraded in soils.

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