엔도술판

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H410：장기적 영향에 의해 수생생물에 매우 유독함

• 예방조치문구

  P260：분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.

  P262：눈, 피부, 의복에 묻지 않도록 하시오.

  P273：환경으로 배출하지 마시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

엔도술판 화학적 특성, 용도, 생산

• 개요

  Endosulfan (70) [115-29-7], 6,7,8,9,10,10- hexachloro-1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3,- benzo-dioxathiepine 3-oxide (IUPAC) [The technical product is a mixture of two isomers: α-endosulfan: 3α,5αβ,6α, 9α,9αβ (64–67%) (70a) and β-endosulfan 3α,5aα,6β,9β, 9aα, (29–32%) (70b)]; [959-98-8] (formerly [33213-66- 0]) (β-endosulfan);[33213-65-9] (formerly [891-86-1] and [19670-15-6]) (β-endosulfan) is the adduct of hexachlorocyclopentadiene and 1,4-dihydroxy-2-butene reacted further with SOCl2 to produce 6,7,8,9,10,10-hexachloro- 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxa thiepin-3-oxide. The technical product is a brownish solid, mp 70–100 ?C, vapor pressure 1.3 mPa at 25 ?C, soluble in petroleum solvents but having low solubility in water. It consists of about four parts of α-isomer (mp 108 ?C, cis with regard to the sulfite group) and one part of the β-isomer (mp 206 ?C, trans with regard to the sulfite group). The α-isomer, which is somewhat more insecticidal, is slowly converted to the more stable β-isomer at high temperature, and both isomers are oxidized slowly to endosulfan sulfate [1031-07-8] (mp 181 ?C). In acid media, both isomers form endosulfan diol [2157-19-9] (mp 203 ?C).

• 화학적 성질

  (commercial product): Brown crystals. Mixture of two isomers.

• 용도

  Insecticide.

• 정의

  ChEBI: A cyclic sulfite ester that is 1,5,5a,6,9,9a-hexahydro-6,9-methano-2,4,3-benzodioxathiepine 3-oxide substituted by chloro groups at positions 6, 7, 8, 9, 10 and 10.

• 일반 설명

  Endosulfan is a pesticide. It is a cream- to brown-coloured solid that may appear in the form of crystals or flakes. It has a smell like turpentine, but does not burn. It does not occur naturally in the environment. It is a restricted use pesticide, meaning that it can only be used by professional applicators.

• 공기와 물의 반응

  Sightly soluble in water. Slowly hydrolyzes to form sulfur dioxide and a diol; hydrolyzes more rapidly under basic or acidic conditions.

• 반응 프로필

  Thiosulfan is an organochlorine, cyclodiene derivative. Thiosulfan is also a sulfite ester. Halogenated aliphatic or cyclic alkane compounds are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. As Thiosulfan is rather highly substituted Thiosulfan may be resistant to reaction. However, materials in this group are incompatible with strong oxidizing and reducing agents. Also, they may be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. As an ester, Thiosulfan will hydrolyze to form sulfur dioxide and diol; reaction is more rapid under basic conditions.

• 위험도

  Toxic by ingestion, inhalation, and skin absorption; use may be restricted. Lower respiratory tract irritant; liver and kidney damage. Questionable carcinogen.

• 건강위험

  Thiosulfan is very toxic. The probable oral lethal dose is 50 to 500 mg/kg, or 1 teaspoonful to 1 ounce for a 150 lb. person.

• 화재위험

  Container may explode in heat of fire. Fire or run off from fire control water may release irritating or poisonous gases. Slowly oxidizes in air. Do not store at temperature below 20F.

• 농업용

  Insecticide, Acaricide: A U.S. EPA restricted Use Pesticide (RUP). Not approved for use in EU countries. Globally banned as of April 29, 2010. Endosulfan was added to the list of Stockholm Convention Persistent Organic Pollutants (POPs): Annex A (Elimination). Endosulfan is a chlorinated hydrocarbon insecticide and acaricide of the cyclodiene subgroup which acts as a poison to a wide variety of insects and mites on contact. Although it may also be used as a wood preservative, it is used primarily on a wide variety of food crops including tea, coffee, fruits, and vegetables, as well as on rice, cereals, maize, sorghum, or other grains. Formulations of endosulfan include emsulsifiable concentrate, wettable powder, ultra-low volume (ULV) liquid, and smoke tablets. It is compatible with many other pesticides and may be found in formulations with dimethoate, malathion, methomyl, monocrotophos, pirimicarb, triazophos, fenoprop, parathion, petroleum oils, and oxine-copper. It is not compatible with alkaline materials. Technical endosulfan is made up of a mixture of two molecular forms (isomers) of endosulfan, the alpha-and beta-isomers.

• 상품명

  AFIDEN®; BEOSIT®; BIO 5,462®; CHLORTHIEPIN®; CLEAN-CROP®; CRISUFAN®; CYCLODAN®; DE-PESTER®; DESTROY®; DEVISULPHAN®; DISSULFAN CE®; ENDOCEL® ENDOCIDE®; ENDOSOL®; END-O-SULFAN®; ENDOTAF®; ENDOX®; ENSURE®; E-Z FLO®; FMC 5462®; HEXASULFAN®; HILDAN®; HOE 2671®; INSECTO®; INSECTOPHENE®; KENDAN®; KERNTOX®; KOP-THIODAN®; MALIX®; MALUX; MAUX®; MOS-570; METHOFAN®; NCI-C00566; NIA 5462®, NIAGARA 5,462; NIAGARA 5,462®[C]; PHASER®; RASAYANSULFAN; ROCKY®; THIFOR®; THIDAN®; THIMUL®; THIODAN®; α-THIODAN®; β-THIODAN®; THIONEX; α-THIONEX®; β-THIONEX®; THIOKILL®; THIOFOR®; THIONEX®; THIOSULFAN®; THIOSULFAN THIONEL®; THISULFAN TIOVEL; TIONEL; TIOVEL®

• Pharmacology

  The rat LD₅₀ values are 43, 18 mg/kg (oral) and 130, 74 mg/kg (dermal). The α-isomer has somewhat greater insecticidal activity and is slowly converted to the more stable β-isomer at a high temperature. Both isomers oxidize slowly in air and in biological systems to endosulfan sulfate [1031-07-8], mp 181–182 ?C. In acid media, both isomers form endosulfan diol [2157-19-9], mp 203–205 ?C.
  Endosulfan is a broad-spectrum insecticide used to control pests of vegetables, fruit, field crops, and ornamentals. Unlike other cyclodiene insecticides, it is biodegradable by hydrolysis at the sulfite ester bonds and is more readily metabolized. It is also less persistent on plant surfaces, and 50% of the residues are lost in 3–7 days. Volatilization may be the major route of loss.
  Endosulfan is readily hydrolyzed in water to the diol (74), but it is moderately persistent in soil. Endosulfan (α- and β-endosulfan) is degraded in soil with DT₅₀ 30 to 70 days. The major metabolite is usually endosulfan sulfate (71), which is degraded more slowly. In the field DT₅₀ for total endosulfan (α- and β-endosulfan and endosulfan sulfate) is 5 to 8 months.

• Safety Profile

  Poison by ingestion, inhalation, skin contact, intraperitoneal, and subcutaneous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen with experimental tumorigenic and neoplastigenic data. Human systemic effects: convulsions, cyanosis. Human mutation data reported. A central nervous system stimulant producing convulsions. A htghly toxic organochlorine pesticide that does not accumulate significantly in human tissue. Absorption is normally slow, but is increased by alcohols, oil, and emulsifiers. When heated to decomposition it emits toxic fumes of Cl and SOx. See also CHLORIDES and SULFITES

• 잠재적 노출

  Those engaged in the manufacture, formulation, and application of this material

• Carcinogenicity

  Equivocal results have been found in genotoxic assays, but endosulfan was mutagenic and clastogenic and induced effects on cell cycle kinetics in various in vivo and in vitro tests.
  In reproductive studies, male rats treated at 3.0 mg/kg from day 15 to 21 of gestation had reduced sperm production in adulthood.
  The 2003 ACGIH threshold limit value-time-weighted average (TLV-TWA) is 0.1mg/m3 with a notation for skin absorption.

• 신진 대사 경로

  When endosulfan is incubated with microorganisms, endosulfan is extensively degraded in nitrogen- deficient, carbon-deficient, and nitrogen-rich cultures of Phanerochaete chrysosporium and is primarily oxidized to endosulfan sulfate, which is a terminal end product, or hydrolyzed to the non-sulfur-containing metabolites. An initial hydrolysis of endosulfan results in the formation of the intermediate metabolite or endosulfan diol, which further undergoes oxidation to yield endosulfan hydroxyether followed by the formation of endosulfan lactone or tentatively identified endosulfan dialdehyde.

• 운송 방법

  UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

• 비 호환성

  Those engaged in the manufacture, formulation, and application of this material

• 폐기물 처리

  A recommended method for disposal is burial 18 in deep in noncropland, away from water supplies, but bags can be burned. Large quantities should be incinerated at high temperature in a unit with effluent gas scrubbing. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/ mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.

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