Lomefloxacin hydrochloride

한글명:Lomefloxacin hydrochloride

카스 번호98079-52-8

상품명:Lomefloxacin hydrochloride

CBNumberCB5723616

분자식C17H20ClF2N3O3

포뮬러 무게387.81

MOL 파일98079-52-8.mol

화학적 성질

녹는점	290-3000C
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	1M NaOH: 용해성50mg/mL
물리적 상태	powder to crystal
색상	흰색에서 황백색까지
Merck	14,5562
CAS 데이터베이스	98079-52-8(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

WGK 독일

RTECS 번호

VB1997500

HS 번호

29339900

NFPA 704:

	0
1		0

그림문자(GHS)

Lomefloxacin hydrochloride 화학적 특성, 용도, 생산

개요
Lomefloxacin hydrochloride is the hydrochloride form of Lomefloxacin. Lomefloxacin is a bactericidal fluoroquinolone agent that is active against gram-negative and gram-positive organisms. Lomefloxacin inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, which are needed for the transcription and replication of bacterial DNA. DNA gyrase is thought to be the primary quinolone target for gram-negative bacteria. Topoisomerase IV is thought to be the primary target in gram-positive organisms. The inhibition of the topoisomerases results in strand breakage of the bacterial chromosome, supercoiling, and resealing. Therefore, DNA replication and transcription is inhibited. Lomefloxacin can be used to treat many kinds of infections such as respiratory, urinary tract, obstetric, gynaecological, joint, skin, oral, ear, nose, throat and eye infections. Compared with other quinolone antibacterial drugs, lomefloxacin has certain advantages such as convenient administration and no necessity of theophylline dosage adjustment.
화학적 성질
White powder with no smell, bitter taste
용도
Fluorinated quinolone antibacterial. DNA gyrase antagonist
정의
ChEBI: The hydrochloride salt of lomefloxacin. It is administered by mouth to treat bacterial infections including bronchitis and urinary tract infections. It is also used topically as eye drops for the treatment of bacterial conjunctivitis, and as ear drops for he treatment of otitis externa and otitis media.
참고 문헌
Wadworth, A. N., and K. L. Goa. "Lomefloxacin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. " Drugs 42.6(1991): 1018-60.
Symonds, W. T., and D. E. Nix. "Lomefloxacin and temafloxacin: two new fluoroquinolone antimicrobials." Clin Pharm 11.9(1992): 753-66.

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