헤스페레틴

한글명:헤스페레틴

카스 번호520-33-2

상품명:Hesperetin

CBNumberCB4304735

분자식C16H14O6

포뮬러 무게302.28

MOL 파일520-33-2.mol

동의어(한글)

헤스페레틴

화학적 성질

녹는점	230-232°C
끓는 점	363.32°C (rough estimate)
밀도	1.2514 (rough estimate)
굴절률	-4 ° (C=1.8, EtOH)
저장 조건	Inert atmosphere,Room Temperature
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨)
산도 계수 (pKa)	7.49±0.40(Predicted)
물리적 상태	고체
물리적 상태	단단한 모양
색상	흰색에서 연한 노란색
수용성	물(일부), 묽은 알칼리 및 에탄올(50mg/ml)에 용해됩니다.
Merck	14,4670
BRN	309850
InChIKey	AIONOLUJZLIMTK-AWEZNQCLSA-N
LogP	2.90
CAS 데이터베이스	520-33-2(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36/37/38

안전지침서

26-36/37/39-27-37

WGK 독일

HS 번호

29329990

NFPA 704:

	1
2		0

그림문자(GHS)

헤스페레틴 화학적 특성, 용도, 생산

개요
Hesperetin is a flavonoid that has been found in citrus fruits and has diverse biological activities. It reduces ApoB protein levels, ACAT2 expression, and LDL degradation in HepG2 cells when used at a concentrations ranging from 10 to 200 μM. Hesperetin inhibits IgG-induced β-hexosaminidase release from RBL-2H3 cells (IC₅₀ = 0.099 mg/ml). It inhibits LPS-induced nitric oxide (NO) production and reduces levels of inducible nitric oxide synthase (iNOS), IL-6, and IL-1β in BV-2 microglial cells. Hesperetin (5 mg/kg) inhibits passive cutaneous anaphylaxis in mice. It reduces body weight loss, colon shortening, and ulcer severity in a mouse model of TNBS-induced ulcerative colitis. Hesperetin reduces cortical and hippocampal neuronal apoptosis and increases time spent in the target quadrant in the Morris water maze in a mouse model of LPS-induced neuronal inflammation.
화학적 성질
Beige to Light Brown Crystalline Solid
용도
(±)-Hesperetin is an antioxidant flavonoid. Induces G1-phase cell cycle arrest. Anti-inflammatory. (±)-Hesperetin suppresses NF-κB activation. Reduces cholesterol biosynthesis. Inhibits lipid peroxidation. Neuroprotective against neuronal oxidative damage.
정의
ChEBI: Hesperetin is a trihydroxyflavanone having the three hydroxy gropus located at the 3'-, 5- and 7-positions and an additional methoxy substituent at the 4'-position. It has a role as an antioxidant, an antineoplastic agent and a plant metabolite. It is a monomethoxyflavanone, a trihydroxyflavanone, a member of 3'-hydroxyflavanones and a member of 4'-methoxyflavanones. It is a conjugate acid of a hesperetin(1-).
Purification Methods
Crystallise it from EtOAc or ethanol. The natural S(-) form crystallises from EtOH and has m 216-218o and [] D -37.6o (c 2, EtOH). Note that C2 is chiral. [Beilstein 18 II 204, 18 III/IV 3215, 18/5 V 214.]

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