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순도시험
(1) 비소 : 이 품목을 비소시험법에 따라 시험할 때, 그 양은 4.0ppm 이하이어야 한다.
(2) 납 : 이 품목 5.0g을 취하여 원자흡광광도법 또는 유도결합플라즈마발광광도법에 따라 시험할 때, 그 양은 2.0ppm 이하이어야 한다.
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확인시험
(1) 이 품목의 에탄올용액(1→100,000)은 파장 234～238nm 및 320～324nm에 극대흡수부가 있다.
(2) 이 품목 0.01g에 알콜성10%수산화칼륨시액 10mL를 가하여 가온하여 녹일 때, 액은 황색을 나타낸다.
(3) 이 품목 0.01g에 아세톤 2mL를 가하여 녹이고 염화제이철에탄올용액(1→50) 0.1mL를 가할 때, 액은 적갈색을 나타낸다.
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정량법
이 품목을 건조한 다음 약 0.5g을 정밀히 달아 50v/v% 에탄올용액 50mL를 가해 주고 수욕상에서 가열용해시키고 냉각시킨 다음 0.1N 수산화나트륨용액으로 적정한다. 따로 같은 방법으로 공시험을 한다.
0.1N 수산화나트륨용액 1mL = 19.418mg C10H10O4
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정의
이 품목은 벼과 벼(Oryza sativa LINNE)에서 얻어진 미강유를 실온의 약알칼리성하에서 함수에탄올 및 헥산으로 분배시킨 다음 함수에탄올 획분에 얻어진 γ-오리자놀을 가압하의 뜨거운 황산으로 가수분해한 다음 이를 정제하여 얻어지는 것으로서 그 주성분은 페룰린산이다.
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강열잔류물
이 품목 5g을 취하여 강열잔류물시험법을 할 때, 그 양은 0.1% 이하이어야 한다.
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개요
Ferulic acid is widely found in plants, especially in artichoke, eggplant and corn
bran. In addition, it is also present in a variety of Chinese herbal medicines, such as
angelica, dome, motherwort, snow ganoderma lucidum and so on.
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화학적 성질
Ferulic acid is a pale yellow solid, It belongs to the family of hydroxycinnamic acids. It is an abundant phenolic phytochemical found in plant cell wall components. Natural sources of ferulic acid are leaves and seeds of many plants, such as cereals, coffee, apples, artichokes, peanuts, oranges, pineapples and wine.
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물리적 성질
Appearance: light yellow crystalline powder. Solubility: slightly soluble in cold
water; soluble in hot water, with poor stability in aqueous solution; easily decomposed when encounter light; soluble in ethanol and ethyl acetate; slightly soluble in
ether; insoluble in benzene and petroleum ether. Melting point: 170–173?°C.
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역사
Ferulic acid was first isolated from the medicinal plants ferulic in 1866. The biologi_x005fcal activity of ferulic acid was not revealed until 1957 when the pioneering study of
Preziosi P in Italy showed for the first time the efficacy of ferulic acid in regulating
blood lipids and diuretic . In 1979, Lin Mao and others isolated ferulic acid from
the Chinese medicine angelica and reported that ferulic acid had the inhibitory
effect on platelet aggregation . Since then, more and more medicinal efficacy of
ferulic acid has gradually been recognized.
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용도
ferulic acid is a plant-derived anti-oxidant and free-radical scavenger, it protects the skin against uVB-induced redness. When incorporated into formulas with ascorbic acid and tocopherol, ferulic acid can improve their stability and double the photoprotection capacities offered by the formulation. In clinical studies, ferulic acid exhibits good permeation capacities through the stratum corneum, which can be attributed to its lipophilic properties.
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정의
A plant growth
inhibitor.
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Indications
This product is mainly used for the treatment of atherosclerosis, coronary heart
disease and ischemic cerebrovascular disease.
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Pharmacology
Orally administered ferulic acid completely prevents the formation of skin tumors, reverts the status of phase I and phase II detoxication agents, lipid peroxidaton byproducts and antioxidants to near-normal ranges in 7,12-DMBA-treated mice (Alias et al., 2009). The observation demonstrate that orally administered ferulic acid has potent suppressive effects on cell proliferation during DMBA-induced skin carcinogenesis.
Ferulic acid also has the capacity to prevent UV-induced damage to cells. Ferulic acid is often added as an ingredient to anti-aging supplements. When ferulic acid was incorporated into a formulation of α-tocopherol and/or ascorbic acid, the topical delivery of the vitamins was improved. There was enhanced chemical stability and the photoprotection to solar-simulated irradiation doubled (Lin et al., 2005; Cassano et al., 2009). For example, Murray et al. (2008) applied a stable topical formulation (containing 1% α-tocopherol, 15% L-ascorbic acid, and 0.5% ferulic acid) to normalappearing human skin and a pig skin model. These were then irradiated with solar-simulated UV. The results showed the complex of antioxidants provided substantial UV photoprotection against erythema, sunburnt cells, thymine dimmers, p53 as well as UV-induced cytokine formation including IL-1α, IL-6, IL-8, and IL-10, and TNF-α (Murray et al., 2008).
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Clinical Use
At present, there are sodium ferulate tablets and ferulic acid injection used in clinic.
Sodium ferulate tablets are mainly used for the adjuvant therapy of atherosclerosis,
coronary heart disease, cerebrovascular disease, glomerular disease, pulmonary
hypertension, diabetic vascular disease, vasculitis and other vascular disorders.
Ferulic acid can also be used for the treatment of migraine headache and vascular
headache. Ferulic acid injection is mainly used for the treatment of ischemic cardiovascular and cerebrovascular disease. In addition, sodium ferulate combined with
atorvastatin can be used for the treatment of pulmonary hypertension, diabetic
nephropathy and chronic glomerulonephritis in clinic .
Ferulic acid is also used in combination with other drugs to treat other diseases.
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부작용
Ferulic acid serums and creams are generally safe for most skin types. However, it's not safe for everyone.
Sensitive skin. This can cause: Mild redness, Irritation.
Allergic to bran or oatmeal. People may also have an allergy to ferulic acid serums derived from bran or oats. Symptoms tend to be mild and may include: Redness, Swelling, Itching, Rash, and Peeling.
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Purification Methods
Crystallise ferulic acid from H2O. [Beilstein 10 H 436, 10 IV 1776.]
