1H-테트라졸

한글명:1H-테트라졸

카스 번호288-94-8

상품명:Tetrazole

CBNumberCB4230898

분자식CH2N4

포뮬러 무게70.05

MOL 파일288-94-8.mol

동의어(한글)

1H-테트라졸

화학적 성질

녹는점	156-158°C
끓는 점	220℃
밀도	0.798 g/mL at 20 °C
굴절률	n20/D 1.348
RTECS 번호	UW7370000
인화점	5 °C
저장 조건	Room temperature.
용해도	DMSO및메탄올에 용해됨
물리적 상태	액체
산도 계수 (pKa)	4.9(at 25℃)
색상	크림부터 오렌지까지
수용성	녹는
분해온도	220°C
BRN	105799
안정성	RT에서 안정적
InChIKey	KJUGUADJHNHALS-UHFFFAOYSA-N
CAS 데이터베이스	288-94-8(CAS DataBase Reference)
NIST	1H-Tetrazole(288-94-8)
EPA	1H-Tetrazole (288-94-8)

위험 및 안전 성명

위험품 표기	F,Xn,E
위험 카페고리 넘버	11-20/21/22-36-5-4
안전지침서	16-26-36-36/37-35-15
유엔번호(UN No.)	UN 1993 3/PG 2
WGK 독일	3
F 고인화성물질	3-4.15-10
위험 등급	4.1
포장분류	III
HS 번호	29339900

그림문자(GHS)

1H-테트라졸 MSDS

1H-테트라졸 화학적 특성, 용도, 생산

화학적 성질
white crystals or crystalline powder
용도
Tetrazole is a catalyst for phosphoramidite synthesis. It is also used as an intermediate for the drug cilostazol. Cilostazol is an antiplatelet drug and a vasodilator. Tetrazole derivatives are used as antibiotics and optically active tetrazole-containing antifungal preparations of azole type was reported.
제조 방법
The first tetrazole synthesis was reported in 1885.
Tetrazole Synthesis: Nano-TiCl4.SiO2 (0.1 g) was added to a mixture of benzonitrile (1 mmol), sodium azide (2 mmol) in DMF (5 mL) at reflux for 2 h. After completion of reaction (as monitored by TLC), the mixture was allowed to cool to room temperature, the catalyst was removed by filtration. Then by adding ice water and 4N HCl (5 mL) to the residue, a white solid was obtained. This was then washed with cold chloroform. This simple procedure yielded pure tetrazole with good yields.
정의
ChEBI: 1H-tetrazole is a tetrazole tautomer where the proton is located on the 1st position. It is a tetrazole and a one-carbon compound. It is a tautomer of a 2H-tetrazole and a 5H-tetrazole.
주요 응용
1H-Tetrazole is used as a bioisostere for the carboxylate group. It is also used as coupling reagent for preparation of polynucleotides.
일반 설명
Tetrazole is an odorless white to light-yellow crystalline powder. Mp:1 55-157°C. When heated to decomposition Tetrazole emits toxic oxides of nitrogen fumes. Can explode if exposed to shock or heat from friction or fire. The primary hazard is from blast effect where the entire load can explode instantaneously and not from flying projectiles and fragments.
건강위험
Fire may produce irritating, corrosive and/or toxic gases.
화재위험
MAY EXPLODE AND THROW FRAGMENTS 1600 meters (1 MILE) OR MORE IF FIRE REACHES CARGO.
Purification Methods
Crystallise the tetrazole from EtOH and sublime it under high vacuum at ca 120o (care should be taken due to possible EXPLOSION). [Beilstein 26 H 346, 26 I 108, 26 II 196, 26 III/IV 1652.]

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