Tamsulosin hydrochloride

한글명:Tamsulosin hydrochloride

카스 번호106463-17-6

상품명:Tamsulosin hydrochloride

CBNumberCB3410080

분자식C20H29ClN2O5S

포뮬러 무게444.97

MOL 파일106463-17-6.mol

화학적 성질

녹는점	228-230°C
알파	D24 -4.0° (c = 0.35 in methanol)
RTECS 번호	DB2430000
저장 조건	2-8°C
용해도	DMSO: >10mg/mL
물리적 상태	백색분말
색상	흰색에서 황백색까지
Merck	14,9049
InChIKey	ZZIZZTHXZRDOFM-XFULWGLBSA-N
CAS 데이터베이스	106463-17-6(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

22-36/37/38

안전지침서

WGK 독일

HS 번호

29350090

NFPA 704:

	0
3		0

그림문자(GHS)

Tamsulosin hydrochloride 화학적 특성, 용도, 생산

개요
Tamsulosin is a potent antagonist of α₁-adrenergic receptors (α₁-ARs; K_i = 0.229 nM in a radioligand binding assay). It is 3,800-fold selective for α₁-ARs over α₂-ARs (K_i = 871 nM). Tamsulosin antagonizes norepinephrine-induced contraction of isolated rabbit aorta (pA₂ = 10.11) but has no effect on contraction stimulated by histamine, serotonin , angiotensin II , or prostaglandin F_2α . In vivo, tamsulosin reverses the pressor effect of phenylephrine (Item Nos. 17205 | 18619) in pithed rats. It reversibly reduces fertility in male rats when administered at a dose of 0.15 mg/kg. Tamsulosin (1-100 μg/kg) also reduces prostatic pressure in a dose-dependent manner with minimal hypotensive effects in anesthetized dogs. Formulations containing tamsulosin have been used for the treatment of benign prostatic hyperplasia.
화학적 성질
White to Off-White Solid
용도
Specific a1-adrenoceptor antagonist. Used in the treatment of benign prostatic hypertrophy
일반 설명
Tamsulosin hydrochloride is a subtypeselective a₁A and a₁D adrenoceptor antagonist, which exists in two enantiomeric forms, of which the R-isomer is the pharmaceutically active component. It is used to reduce urinary obstruction and is also involved in relieving the symptoms associated with symptomatic benign prostatic hyperplasia.
위험도
Moderately toxic by ingestion.
생물학적 활성
Selective α 1A -adrenoceptor antagonist (pK i values are 9.97, 9.64 and 8.86 for α 1A , α 1B and α 1D subtypes respectively). Decreases resting maximal urethral pressure with negligable effect on mean arterial blood pressure in vivo .

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