Nadifloxacin

한글명:Nadifloxacin

카스 번호124858-35-1

상품명:Nadifloxacin

CBNumberCB3301560

분자식C19H21FN2O4

포뮬러 무게360.38

MOL 파일124858-35-1.mol

화학적 성질

녹는점	245-2470C (dec)
끓는 점	624.9±55.0 °C(Predicted)
밀도	1.46±0.1 g/cm3(Predicted)
저장 조건	Sealed in dry,Store in freezer, under -20°C
용해도	DMSO(약간 용해됨), 메탄올(약간 용해됨, 가열)
물리적 상태	백색 내지 황색 결정성 고체.
산도 계수 (pKa)	5.55±0.40(Predicted)
색상	흰색에서 황백색까지
Merck	14,6345
InChI	InChI=1S/C19H21FN2O4/c1-10-2-3-12-16-13(18(24)14(19(25)26)9-22(10)16)8-15(20)17(12)21-6-4-11(23)5-7-21/h8-11,23H,2-7H2,1H3,(H,25,26)
InChIKey	JYJTVFIEFKZWCJ-UHFFFAOYSA-N
SMILES	C12=CC(F)=C(N3CCC(O)CC3)C3=C1N(C(C)CC3)C=C(C(O)=O)C2=O
CAS 데이터베이스	124858-35-1(CAS DataBase Reference)

위험 및 안전 성명

HS 번호	2933.99.7500
독성	LD50 male, female mice and rats (mg/kg): 376.5, 420.6, 225.7, 240.5 i.v. (Hashimoto)

그림문자(GHS)

Nadifloxacin MSDS

Nadifloxacin 화학적 특성, 용도, 생산

개요
Nadifloxacin, one of the three new fluoroquinolone antibiotics launched in 1993 is indicated for topical treatment of acne vulgaris and other skin infections. Nadifloxacin has a potent and broad spectrum of activity against aerobic Gram-positive and -negative bacteria and against anaerobic bacteria. It produces significant improvement in patients with Propionibacterium acnes infection and does not appear to cause cross-resistance to other antibiotic agents. Its potent antimicrobial activity has also been demonstrated in the Pseudomonas aeruginosa burn wound infection model in mice. Nadifloxacin exerts its antibiotic activity by inhibiting the formation of supercoiled DNA by DNA gyrase.
화학적 성질
Off-White Crystalline Solid
용도
Nadifloxacin is a topical fluorinated quinolone antibacterial used to treat skin conditions such as acne and other dermal infections caused by bacteria. This drug belongs to a class of calcium salt of polyacrylic acid crosslinked with divinyl glycol with minimal AEs.
정의
ChEBI: Nadifloxacin is a pyridoquinoline, a hydroxypiperidine, a heteroarylpiperidine and a quinolone antibiotic. It has a role as an antibacterial drug. It is effective against the Gram-positive bacteria S. aureus and P. acnes, as well as Gram-negative bacteria.
Pharmaceutical Applications
A lipophilic tricyclic fluorobenzoquinoline with a 4- hydroxylpiperinyl moiety at the C-8 position, formulated as a cream for topical use. It is active against many Grampositive bacteria involved in skin infections, including Propionibacterium acnes (MIC 0.25–2.0 mg/L), and Staph. aureus (MIC 0.015–2 mg/L). It appears to inhibit the generation of reactive oxygen species by neutrophils. The sodium salt is used as a 1% cream for use in acne vulgaris and cutaneous staphylococcal infections.

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