Alosetron염산염

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H301：삼키면 유독함

  H319：눈에 심한 자극을 일으킴

  H412：장기적 영향에 의해 수생생물에 유해함

• 예방조치문구

  P273：환경으로 배출하지 마시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Alosetron염산염 화학적 특성, 용도, 생산

• 개요

  Lotronex (alosetron) was developed for the treatment of severe irritable bowel syndrome (IBS), and was approved for use by the US Food and Drug Administration (FDA) in 2000. Although Lotronex had a relatively high improvement rate in patients taking the drug for IBS, it was voluntarily pulled from the market by GlaxoWellcome that same year due to reports of severe adverse side effects, some resulting in death.
  In 2002, Lotronex was reapproved in a supplemental New Drug Application for use under more restrictive conditions. Now with a risk management program to be consulted prior to administration of the drug, Lotronex is designated to be prescribed only when its medical benefits outweigh the risks of toxic effects; women with severe diarrhea-predominant IBS are now the focal point of prescriptions for Lotronex.

• 화학적 성질

  Alosetron hydrochloride is Crystalline Solid

• 용도

  Alosetron hydrochloride is used in treatment of irritable bowel syndrome

• 정의

  ChEBI: The hydrochloride salt of alosetron.

• 환경귀착

  The environmental fate and behavior of Lotronex is uncertain, as formal studies regarding its release into the environment are virtually nonexistent in the literature. Limited water solubility (61 mg ml^-1) may lead to persistence in soils, and in sediment following aquatic release, although specific fates with regard to degradation, bioaccumulation, and transport are unknown.

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