Menatetrenone

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Danger

• 유해·위험 문구

  H225：고인화성 액체 및 증기

  H319：눈에 심한 자극을 일으킴

• 예방조치문구

  P210：열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

  P305+P351+P338：눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.

Menatetrenone 화학적 특성, 용도, 생산

• 개요

  Menatetrenone (also known as MK-4) is a manaquinone compound and a vitamin K compound which can be used as a hemostatic agent as well as adjunctive therapy for the pain of osteoporosis. It mainly takes effects through modulating the signaling of certain tyrosine kinases, thereby affecting several transcription factors including c-myc and c-fos. It is capable of inhibiting tumor cells growth through inducing apoptosis and cell cycle arrest. It can be produced via the conversion of vitamin K1 inside the body including the testes, pancreas and arterial walls.

• 화학적 성질

  A yellow crystal is extracted from acetone-ethanol or methanol-chloroform. It has a molecular weight of 580.90 and a melting point of 51-52°C. It is insoluble in water but slightly soluble in oil. It dissolves well in ethanol, ether, acetone, benzene, chloroform, and other organic solvents. However, its solubility is slightly lower than that of vitamin K1. It decomposes when exposed to strong acid, oxidants, alkalis, and light.

• 출처

  Menatetrenone (vitamin K2) is widely found in green leaves and vegetables, and also in fish, meat, cheese and liver oil.

• 제조 방법

  It can be extracted from millet leaves and rotten fish, and can also be synthesized with 2-menaquinone-1,4.

• 정의

  ChEBI: Menaquinone-4 is a menaquinone whose side-chain contains 4 isoprene units in an all-trans-configuration. It has a role as a bone density conservation agent, a human metabolite, an antioxidant, an anti-inflammatory agent and a neuroprotective agent.

• 일반 설명

  Menaquinone (K2), a vitamin K2 homologue with four isoprene units. It has been reported to enhance bone formation and plays a vital role in the production of blood coagulation factors.

• 참고 문헌

  https://pubchem.ncbi.nlm.nih.gov/compound/menatetrenone#section=Biomolecular-Interactions-and-Pathways
  https://en.wikipedia.org/wiki/Menatetrenone

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