D-Thyroxine

한글명:D-Thyroxine

카스 번호51-49-0

상품명:D-Thyroxine

CBNumberCB2276186

분자식C15H11I4NO4

포뮬러 무게776.87

MOL 파일51-49-0.mol

화학적 성질

녹는점	~235 °C (dec.)
알파	21546 +2.97° (0.74 g in 6 g of 0.5N NaOH and 14 g of alcohol)
끓는 점	576.3±50.0 °C(Predicted)
밀도	2.4440 (estimate)
저장 조건	Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
용해도	산성알코올(약간 용해됨), 산성수(약간 용해됨, 초음파 처리), 수성 염기(약간 용해됨)
물리적 상태	고체
물리적 상태	단단한 모양
산도 계수 (pKa)	2.12±0.30(Predicted)
색상	미색부터 베이지까지
안정성	흡습성
CAS 데이터베이스	51-49-0(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

20/21/22-40

안전지침서

36/37-36-22

WGK 독일

F 고인화성물질

8-10

NFPA 704:

	0
1		0

그림문자(GHS)

D-Thyroxine MSDS

D-Thyroxine 화학적 특성, 용도, 생산

화학적 성질
beige to light grey powder
용도
One of the thyroid hormones involved in the maintenance of metabolic homeostasis. Synthesized and stored as amino acid residues of thyroglobulin, the major protein component of the thyroid follicular colloid. Synthesis and secretion are regulated by the pituitary hormone (TSH). Deiodinated in peripheral tissues to the active metabolite, liothyronine. The D-form has very little activity as a thyroid hormone, but has been used to treat hyperlipidemia.
정의
ChEBI: The D-enantiomer of thyroxine.
Biological Functions
Dextrothyroxine, the synthetic D-(+)-stereoisomer isomer of L-(–)-T4, was introduced in hypocholesteremichypolipidemic therapy with the premise that it would be void of calorigenic effects. The possibility of trace contamination with and metabolic conversion to T4 and congeners has restricted its use, however, especially in patients with coronary heart disease.
Mechanism of action
Dextrothyroxine speeds up the decomposition of cholesterol and lipoproteins, thus activating catabolism of cholesterol in the liver, which results in cholesterol being more intensively transformed into bile salts. It lowers the level of low-density lipoproteins in the plasma and very low-density lipoproteins in fatty tissue. It is recommended for treating hyperlipoproteinemia.
Purification Methods
Recrystallise D-thyroxine from H2O (needles) or from an ammonical solution by dilution with H2O, MeOH or Me2CO. It has also been purified by dissolving ~6.5 g in a mixture of MeOH (200mL) and 2N HCl (20mL), adding charcoal, filtering then adding NaOAc solution to pH 6. On standing the thyroxine separates, it is filtered off, washed with MeOH then Me2CO and dried in vacuo. N-Formyl-D-thyroxine has m 210o and [] 21 -26.9o (c 5, EtOH). (±)-Thyroxine has m 256o and is purified in the same way. [Nahm & Siedel Chem Ber 96 1 1963, Salter Biochem J 24 471 1930, Beilstein 14 I 671, 14 II 384, 14 III 1566, 14 IV 2374.]

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