프로피온산나트륨

그림문자(GHS)

• 그림문자(GHS)

  

• 신호 어

  Warning

• 유해·위험 문구

  H312：피부와 접촉하면 유해함

• 예방조치문구

  P280：보호장갑/보호의/보안경/안면보호구를 착용하시오.

프로피온산나트륨 화학적 특성, 용도, 생산

• 화학적 성질

  Sodium propionate occurs as colorless transparent crystals or as a granular, free-flowing, crystalline powder. It is odorless, or with a slight characteristic odor, and is deliquescent in moist air. Sodium propionate has a characteristic, slightly cheeselike taste, although by itself it is unpalatable.

• 용도

  Sodium Propionate Hydrate is a food preservative used for its antifungal ability towards grain products.

• 생산 방법

  Sodium propionate is prepared by the reaction of propionic acid with sodium carbonate or sodium hydroxide.

• Pharmaceutical Applications

  As an excipient, sodium propionate is used in oral pharmaceutical formulations as an antimicrobial preservative. Like propionic acid, sodium propionate and other propionic acid salts are fungistatic and bacteriostatic against a number of Gram-positive cocci. Propionates are more active against molds than is sodium benzoate, but have essentially no activity against yeasts.
  Therapeutically, sodium propionate has been used topically in concentrations up to 10% w/w alone or in combination with other propionates, caprylates, or other antifungal agents, in the form of ointments or solutions for the treatment of dermatophyte infections. Eye drops containing 5% w/v sodium propionate have also been used.
  In food processes, particularly baking, sodium propionate is used as an antifungal agent; it may also be used as a flavoring agent in food products. In veterinary medicine, sodium propionate is used therapeutically as a glucogenic substance in ruminants.

• Safety

  Sodium propionate and other propionates are used in oral pharmaceutical formulations, food products, and cosmetics. The free acid, propionic acid, occurs naturally at levels up to 1% w/w in certain cheeses.
  Following oral consumption, propionate is metabolized in mammals in a manner similar to that of fatty acids. Toxicity studies in animals have shown sodium propionate and other propionates to be relatively nontoxic materials.(2,3) In veterinary medicine, sodium propionate is used as a therapeutic agent for cattle and sheep.
  In humans, 6 g of sodium propionate has been administered daily without harm.(2) However, allergic reactions to propionates can occur.
  LD50 (mouse, oral): 6.33 g/kg
  LD50 (mouse, SC): 2.1 g/kg
  LD50 (rabbit, skin): 1.64 g/kg

• 저장

  Sodium propionate is deliquescent and should therefore be stored in an airtight container in a cool, dry place.

• 비 호환성

  Incompatibilities for sodium propionate are similar to those of other weak organic acids.

• Regulatory Status

  GRAS listed. Accepted for use as a food additive in Europe. In cheese products, propionates are limited to 0.3% w/w concentration; a limit of 0.32% w/w is applied in flour and white bread rolls, while a limit of 0.38% w/w is applied in whole wheat products.
  Included in the FDA Inactive Ingredients Database (oral capsules, powder, suspensions, and syrups). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

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