Torasemide

한글명:Torasemide

카스 번호56211-40-6

상품명:Torasemide

CBNumberCB1397929

분자식C16H20N4O3S

포뮬러 무게348.42

MOL 파일56211-40-6.mol

화학적 성질

녹는점	163-164°C
밀도	1.283±0.06 g/cm3(Predicted)
저장 조건	Keep in dark place,Inert atmosphere,Room temperature
용해도	DMSO: 용해성18mg/mL
산도 계수 (pKa)	6.44(at 25℃)
물리적 상태	고체
물리적 상태	단단한 모양
색상	하얀색
수용성	녹는
Merck	14,9552
BCS Class	1
InChIKey	NGBFQHCMQULJNZ-UHFFFAOYSA-N
CAS 데이터베이스	56211-40-6(CAS DataBase Reference)
EPA	3-Pyridinesulfonamide, N-[[(1-methylethyl)amino]carbonyl]-4-[(3-methylphenyl)amino]- (56211-40-6)

위험 및 안전 성명

위험품 표기

위험 카페고리 넘버

36-36/37/38

안전지침서

26-37/39

WGK 독일

RTECS 번호

UT7938000

HS 번호

2935904000

NFPA 704:

	0
2		0

그림문자(GHS)

Torasemide MSDS

Torasemide 화학적 특성, 용도, 생산

개요
Torasemide is a novel loop diuretic launched in 1993 after a 12-year gap from the last diuretic introduction. It is indicated for the treatment of hypertension and edema associated with chronic congestive heart failure, renal disease and hepatic cirrhosis. Torasemide exerts its major diuretic activity on the thick ascending limb of the Henle's loop to promote rapid and marked excretion of water, Na⁺, Cl^-, and to a lesser extent,K⁺and Ca²⁺. Compared with other loop diuretics such as furosemide, torasemide has a stronger antihypertensive action, a higher bioavailability, a longer duration of action that is independent of the renal function, and has no side effects such as paradoxical antidiuresis. The mechanism of its vasodilating effect has been suggested to result from, at least in part, the competitive antagonism of the thromboxane A2 receptor.
화학적 성질
Crystalline Solid
용도
Torasemide is a loop diuretic. Diuretics have been abused as performance-enhancing drugs and masking agents in doping in sports. Use of torsemide is effective for the treatment of edema associated with chronic renal failure. The pharmacology of torasemide is similar to that of frusemide,though torasemide has a longer duration of action with a plasma half-life of approximately 3.5 hours. It also causes a less marked loss of potassiumand calcium.
정의
ChEBI: Torasemide is an N-sulfonylurea obtained by formal condensation of [(3-methylphenyl)amino]pyridine-3-sulfonic acid with the free amino group of N-isopropylurea. It is a potent loop diuretic used for the treatment of hypertension and edema in patients with congestive heart failure. It has a role as a loop diuretic and an antihypertensive agent. It is a N-sulfonylurea, an aminopyridine and a secondary amino compound. It is functionally related to a 4-aminopyridine.

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