Mevastatin

한글명:Mevastatin

카스 번호73573-88-3

상품명:Mevastatin

CBNumberCB1388569

분자식C23H34O5

포뮬러 무게390.51

MOL 파일73573-88-3.mol

화학적 성질

녹는점	151-153 °C
알파	D22 +283° (c = 0.48 in acetone)
끓는 점	555.0±50.0 °C(Predicted)
밀도	1.13±0.1 g/cm3(Predicted)
증기압	0Pa at 25℃
저장 조건	2-8°C
용해도	DMSO: 20mg/mL
산도 계수 (pKa)	13.49±0.40(Predicted)
물리적 상태	가루
색상	하얀색
최대 파장(λmax)	246nm(MeOH)(lit.)
Merck	14,6164
BRN	1269441
InChIKey	AJLFOPYRIVGYMJ-INTXDZFKSA-N
CAS 데이터베이스	73573-88-3(CAS DataBase Reference)

위험 및 안전 성명

위험품 표기	T+
위험 카페고리 넘버	26/27/28
안전지침서	22-24/25-45-36/37/39
WGK 독일	3
RTECS 번호	EK7907100
F 고인화성물질	1-8-10
HS 번호	29322090

그림문자(GHS)

Mevastatin MSDS

Mevastatin 화학적 특성, 용도, 생산

화학적 성질
Off-White Solid
용도
Mevastatin (compactin) is a diterpene produced by several species of the genera Penicillium and Monascus, first reported in 1976. Mevastatin, the prtotype of the statin class, is a potent competitive inhibitor of HMG-CoA reductase, a regulatory enzyme for cholesterol biosynthesis. Mevastatin has also been shown to induce apoptosis by inhibiting post-translational prenylation of proteins such as Ras, increasing eNOS mRNA and protein levels by blocking the geranylgeranylation of Rho, and inhibiting myoblast fusion. It induces cell cycle arrest in late G1 phase and may induce bone morphogenic protein-2 (BMP-2).
정의
ChEBI: A carboxylic ester that is pravastatin that is lacking the allylic hydroxy group and in which the lactone moiety has been hydrolysed to the corresponding delta-hydroxy-carboxylic acid. A hydroxymethylglutaryl-CoA reductase inhibitor (stati ) isolated from Penicillium citrinum and from Penicillium brevicompactum, its clinical use as a lipid-regulating drug ceased following reports of toxicity in animals.
일반 설명
Chemical structure: statin
생물학적 활성
Inhibitor of HMG-CoA reductase; decreases cholesterol biosynthesis, in vitro and in vivo . Induces apoptosis, arrests cancer cells in G1 phase and downregulates cdk 2, 4, and 6, cyclin D1 and E1, p21 and p27.
Purification Methods
Purify compactin by recrystallisation from aqueous EtOH. UV (EtOH): max 230, 237 and 246nm (log 4.28, 4.30 and 4.11); IR (KBr): 3520, 1750 (lactone CO) and 1710 (CO ester) cm-1. [Clive et al. J Am Chem Soc 110 6914 1988, Review: Rosen & Heathcock Tetrahedron 42 4909 1986, IR, NMR, MS: Brown et al. J Chem Soc Perkin Trans 1 1165 1976.] It is a potent inhibitor of 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase), an enzyme in cholesterol biosynthesis, and lowers cholesterol levels [Brown et al. J Biol Chem 253 1121 1978, Nakamura & Ableles Biochemistry 24 1364 1985, Beilstein 18/3 V 145].

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